3-Aminopyridazine - CAS 5469-70-5

Catalog:	BB028782
Product Name:	3-Aminopyridazine
CAS:	5469-70-5
Synonyms:	pyridazin-3-amine

Technical Data

Safety and Hazards

Patents

Literatures

Computed Properties

IUPAC Name:	pyridazin-3-amine
Description:	3-Aminopyridazine (CAS# 5469-70-5) is an important raw material and intermediate used in organic synthesis and pharmaceuticals.
Molecular Weight:	95.10
Molecular Formula:	C4H5N3
Canonical SMILES:	C1=CC(=NN=C1)N
InChI:	InChI=1S/C4H5N3/c5-4-2-1-3-6-7-4/h1-3H,(H2,5,7)
InChI Key:	LETVJWLLIMJADE-UHFFFAOYSA-N
Boiling Point:	326.2 °C at 760 mmHg
Purity:	97.0 %
Density:	1.216 g/cm³
MDL:	MFCD01529869
LogP:	0.64000

Publication Number	Title	Priority Date
WO-2021204626-A1	Aryl and heteroaryl-carboxamide substituted heteroaryl compounds as tyk2 inhibitors	20200406
WO-2021174170-A1	Pyridazine dervatives for modulating nucleic acid splicing	20200228
WO-2021174176-A1	Pyridazine dervatives for modulating nucleic acid splicing	20200228
WO-2021173591-A1	Compounds and methods of use	20200224
WO-2021163556-A1	Compositions and methods for inducible alternative splicing regulation of gene expression	20200212

PMID	Publication Date	Title	Journal
27075367	20160526	Discovery and Characterization of a Highly Potent and Selective Aminopyrazoline-Based in Vivo Probe (BAY-598) for the Protein Lysine Methyltransferase SMYD2	Journal of medicinal chemistry
26496802	20151026	Inhibition of DYRK1A and GSK3B induces human β-cell proliferation	Nature communications
22925448	20121001	Competitive antagonism of insect GABA receptors by iminopyridazine derivatives of GABA	Bioorganic & medicinal chemistry
20126539	20100201	In vivo evaluation of alpha7 nicotinic acetylcholine receptor agonists [11C]A-582941 and [11C]A-844606 in mice and conscious monkeys	PloS one
19223828	20090216	Polyfunctional nitriles in organic syntheses: a novel route to aminopyrroles, pyridazines and pyrazolo[3,4-c]pyridazines	Molecules (Basel, Switzerland)

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Related Functional Groups

Amines and Anilines

[556-90-1]
Pseudothiohydantoin
[1006473-17-1]
[(2,3-Difluorophenyl)methyl][(1,3-dimethylpyrazol-4-yl)methyl]amine
[1106917-71-8]
[3-(Difluoromethoxy)phenyl]methanamine hydrochloride
[1550-50-1]
1,1,2,2-Tetrafluoro-N,N-dimethylethanamine
[1250876-38-0]
1-Cyclopentyl-1H-pyrazole-3,5-diamine
[856848-33-4]
2-Amino-4,5-dibromopyridine

Pyridazines

[92920-33-7]
3,6-Dichloro-4-fluoropyridazine
[19064-64-3]
3,6-Dichloro-4-methylpyridazine
[89179-63-5]
3-Methoxy-4-pyridazinamine
[55271-49-3]
4,5-Dichloropyridazine
[40380-36-7]
5,6-Dimethyl-3-oxo-2,3-dihydropyridazine-4-carbonitrile
[110310-26-4]
4,5-Dichloro-2-(2-methylphenyl)pyridazin-3(2H)-one

GHS Hazard Statement:	H302 (91.11%): Harmful if swallowed [Warning Acute toxicity, oral]
Precautionary Statement:	P264, P270, P280, P301+P312, P305+P351+P338, P330, P337+P313, and P501
Signal Word:	Warning

Complexity:	54.9
Compound Is Canonicalized:	Yes
Covalently-Bonded Unit Count:	1
Defined Atom Stereocenter Count:	0
Defined Bond Stereocenter Count:	0
Exact Mass:	95.048347172
Formal Charge:	0
Heavy Atom Count:	7
Hydrogen Bond Acceptor Count:	3
Hydrogen Bond Donor Count:	1
Isotope Atom Count:	0
Monoisotopic Mass:	95.048347172
Rotatable Bond Count:	0
Topological Polar Surface Area:	51.8 Å²
Undefined Atom Stereocenter Count:	0
Undefined Bond Stereocenter Count:	0
XLogP3:	-1.2