Azido-PEG3-acetic acid - CAS 172531-37-2
Catalog:
BB012833
Product Name:
Azido-PEG3-acetic acid
CAS:
172531-37-2
Synonyms:
Azido-PEG3-CH2CO2H;11-Azido-3,6,9-trioxaundecanoic Acid; N3-PEG3-CH2COOH; {2-[2-(2-Azidoethoxy)ethoxy]ethoxy}acetic acid; Acetic acid, 2-[2-[2-(2-azidoethoxy)ethoxy]ethoxy]-; Azido-PEG3-CH2COOH
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BB012833
5 g
$899
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IUPAC Name: 2-[2-[2-(2-azidoethoxy)ethoxy]ethoxy]acetic acid
Description: N3-PEG3-CH2COOH is a PROTAC linker, which refers to the alkyl/ether composition. N3-PEG3-CH2COOH can be used in the synthesis of a series of PROTACs. N3-PEG3-CH2COOH is a PEG derivative containing an azide group with a terminal carboxylic acid. The hydrophilic PEG spacer increases solubility in aqueous media. The azide group can react with alkyne, BCN, DBCO via Click Chemistry to yield a stable triazole linkage. The terminal carboxylic acid can be reacted with primary amine groups in the presence of activators (e.g. EDC, or DCC) to form a stable amide bond.
Molecular Weight: 233.22
Molecular Formula: C8H15N3O5
Canonical SMILES: C(COCCOCCOCC(=O)O)N=[N+]=[N-]
InChI: InChI=1S/C8H15N3O5/c9-11-10-1-2-14-3-4-15-5-6-16-7-8(12)13/h1-7H2,(H,12,13)
InChI Key: GIXBCECBLAEYKA-UHFFFAOYSA-N
Purity: 95%
Solubility: Soluble in DCM, DMF, DMSO, Water
Appearance: Light Yellow to Brown Clear Liquid
Storage: Store at 2-8°C
LogP: -0.11614
GHS Hazard Statement: H315 (100%): Causes skin irritation [Warning Skin corrosion/irritation]
Precautionary Statement: P264, P280, P302+P352, P305+P351+P338, P321, P332+P313, P337+P313, and P362
Signal Word: Warning
Publication Number Title Priority Date
US-2021102950-A1 Compositions and methods for enrichment and detection of ubiquitin and ubiquitin conjugates 20191002
WO-2020236817-A2 Mcl-1 inhibitor antibody-drug conjugates and methods of use 20190520
WO-2020236825-A2 Mcl-1 inhibitor antibody-drug conjugates and methods of use 20190520
TW-202100184-A Mcl-1 inhibitor antibody-drug conjugates and methods of use 20190520
WO-2019240288-A1 Substance having affinity for antibody, and compound or salt thereof having bioorthogonal functional group 20180614
Complexity: 230
Compound Is Canonicalized: Yes
Covalently-Bonded Unit Count: 1
Defined Atom Stereocenter Count: 0
Defined Bond Stereocenter Count: 0
Exact Mass: 233.10117059
Formal Charge: 0
Heavy Atom Count: 16
Hydrogen Bond Acceptor Count: 7
Hydrogen Bond Donor Count: 1
Isotope Atom Count: 0
Monoisotopic Mass: 233.10117059
Rotatable Bond Count: 11
Topological Polar Surface Area: 79.4 Å2
Undefined Atom Stereocenter Count: 0
Undefined Bond Stereocenter Count: 0
XLogP3: 0.3
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