3-(Cbz-amino)-1,1-difluoro-2-propanol - CAS 1429913-43-8
Catalog: |
BB009480 |
Product Name: |
3-(Cbz-amino)-1,1-difluoro-2-propanol |
CAS: |
1429913-43-8 |
Synonyms: |
N-(3,3-difluoro-2-hydroxypropyl)carbamic acid (phenylmethyl) ester; benzyl N-(3,3-difluoro-2-hydroxypropyl)carbamate |
IUPAC Name: | benzyl N-(3,3-difluoro-2-hydroxypropyl)carbamate |
Description: | 3-(Cbz-amino)-1,1-difluoro-2-propanol (CAS# 1429913-43-8) is used in preparation of of Disubstituted Pyridinecarboxamides as spleen tyrosine kinase inhibitors. |
Molecular Weight: | 245.22 |
Molecular Formula: | C11H13F2NO3 |
Canonical SMILES: | C1=CC=C(C=C1)COC(=O)NCC(C(F)F)O |
InChI: | InChI=1S/C11H13F2NO3/c12-10(13)9(15)6-14-11(16)17-7-8-4-2-1-3-5-8/h1-5,9-10,15H,6-7H2,(H,14,16) |
InChI Key: | AQKIHSUGEPUAMZ-UHFFFAOYSA-N |
LogP: | 1.92970 |
Publication Number | Title | Priority Date |
EP-2763976-A1 | 2-pyridyl carboxamide-containing spleen tyrosine kinase (syk) inhibitors | 20111005 |
EP-2763976-B1 | 2-pyridyl carboxamide-containing spleen tyrosine kinase (syk) inhibitors | 20111005 |
US-2014243336-A1 | 2-Pyridyl Carboxamide-Containing Spleen Tyrosine Kinase (SYK) Inhibitors | 20111005 |
US-9216173-B2 | 2-Pyridyl carboxamide-containing spleen tyrosine kinase (SYK) inhibitors | 20111005 |
WO-2013052394-A1 | 2-pyridyl carboxamide-containing spleen tyrosine kinase (syk) inhibitors | 20111005 |
Complexity: | 233 |
Compound Is Canonicalized: | Yes |
Covalently-Bonded Unit Count: | 1 |
Defined Atom Stereocenter Count: | 0 |
Defined Bond Stereocenter Count: | 0 |
Exact Mass: | 245.0863496 |
Formal Charge: | 0 |
Heavy Atom Count: | 17 |
Hydrogen Bond Acceptor Count: | 5 |
Hydrogen Bond Donor Count: | 2 |
Isotope Atom Count: | 0 |
Monoisotopic Mass: | 245.0863496 |
Rotatable Bond Count: | 6 |
Topological Polar Surface Area: | 58.6 |
Undefined Atom Stereocenter Count: | 1 |
Undefined Bond Stereocenter Count: | 0 |
XLogP3: | 1.7 |
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