2-(Hydroxymethyl)pyrrolidine - CAS 498-63-5

Catalog:	BB026849
Product Name:	2-(Hydroxymethyl)pyrrolidine
CAS:	498-63-5
Synonyms:	2-pyrrolidinylmethanol; pyrrolidin-2-ylmethanol

Technical Data

Safety and Hazards

Patents

Literatures

Computed Properties

IUPAC Name:	pyrrolidin-2-ylmethanol
Description:	2-(Hydroxymethyl)pyrrolidine (CAS# 498-63-5) is an intermediate in the synthesis of Physostigmine and Physostigmine derivative used for treatment of Alzheimer's disease.
Molecular Weight:	101.15
Molecular Formula:	C5H11NO
Canonical SMILES:	C1CC(NC1)CO
InChI:	InChI=1S/C5H11NO/c7-4-5-2-1-3-6-5/h5-7H,1-4H2
InChI Key:	HVVNJUAVDAZWCB-UHFFFAOYSA-N
Boiling Point:	211 °C at 760 mmHg, 98 °C / 14 mmHg
Density:	0.978 g/cm³
LogP:	0.05950

Publication Number	Title	Priority Date
JP-2021155581-A	Methods for Producing Carbon Black Dispersions, Paint Compositions, Coating Films, and Carbon Black Dispersions	20200327
JP-6756938-B1	Method for producing carbon black dispersion, coating composition, coating film, and carbon black dispersion	20200327
WO-2021166627-A1	Dispersion medium for metal particle sintering, and electroconductive paste	20200219
WO-2021158481-A1	Substituted 1,1'-biphenyl compounds and methods using same	20200203
JP-2021120703-A	Photosensitive resin composition, cured relief pattern and its manufacturing method	20200130

PMID	Publication Date	Title	Journal
23050809	20121102	Brønsted acid-assisted intramolecular aminohydroxylation of N-alkenylsulfonamides under heavy metal-free conditions	The Journal of organic chemistry
22585353	20120814	Efficient proline and prolinol ether mediated 3-component synthesis of 3- and 3,4-substituted chromenone derivatives	Organic & biomolecular chemistry
22434659	20120416	Asymmetric Michael addition of N-boc-protected oxindoles to nitroalkenes catalyzed by a chiral secondary amine	Chemistry (Weinheim an der Bergstrasse, Germany)
22480202	20120405	Structure-based classification and ontology in chemistry	Journal of cheminformatics
22374840	20120319	Unifying metal- and organocatalysis for asymmetric oxidative iminium activation: a relay catalytic system enabling the combined allylic oxidation of alcohols and prolinol ether catalyzed iminium reactions	Chemistry (Weinheim an der Bergstrasse, Germany)

Related Products

Online Inquiry

Name:

* Phone:

* Service & Products of Interested:

Project Description:

* Quantity:

* Email:

* Verification Code:

Customer Support

If the product you need is not in our catalog, please contact us in time to submit your needs. You can help our website get better and better. Why not submit the request today?

Submit Requirement

Customer Centered

Global Delivery

Warehouses in multiple cities to ensure fast delivery

Quality Assurance

Strict process parameter control to ensure product quality

Large Stock

> 20,000 building blocks and intermediates from stock

Process Scale-up

Process scale-up from lab to industrial scale

Flexible Batch Size

Flexible batch size for diverse industrial demands

Related Functional Groups

Alcohols and Derivatives

[58287-18-6]
(1R)-1-(4-Nitrophenyl)ethanol
[113724-48-4]
(R)-1-(2-Methoxyphenyl)ethanol
[108100-06-7]
(S)-1-(2-Methoxyphenyl)ethanol
[64437-48-5]
(Z)-10-Hexadecenol
[62972-93-4]
(Z)-11-Octadecen-1-ol
[18621-17-5]
1-Benzhydrylazetan-3-ol

GHS Hazard Statement:	H315 (96.43%): Causes skin irritation [Warning Skin corrosion/irritation]
Precautionary Statement:	P261, P264, P271, P280, P302+P352, P304+P340, P305+P351+P338, P312, P321, P332+P313, P337+P313, P362, P403+P233, P405, and P501
Signal Word:	Warning

Complexity:	56
Compound Is Canonicalized:	Yes
Covalently-Bonded Unit Count:	1
Defined Atom Stereocenter Count:	0
Defined Bond Stereocenter Count:	0
Exact Mass:	101.084063974
Formal Charge:	0
Heavy Atom Count:	7
Hydrogen Bond Acceptor Count:	2
Hydrogen Bond Donor Count:	2
Isotope Atom Count:	0
Monoisotopic Mass:	101.084063974
Rotatable Bond Count:	1
Topological Polar Surface Area:	32.3 Å²
Undefined Atom Stereocenter Count:	1
Undefined Bond Stereocenter Count:	0
XLogP3:	-0.3