Inquiry Basket
Thiazolidines (C3H7NS) are heterocyclic organic compounds with a five-membered saturated ring containing a thioether group at the 1-position and an amine group at the 3-position. Thiazolidines are the colorless liquids of the sulfur analog of oxazolidines. Thiazolidine derivatives have aroused great interest among researchers due to their wide range of biological activities.
Thiazolines (C3H5NS), also known as dihydrothiazoles, are well known as 4,5-dihydro-1,3-thiazole or 4,5-dihydrothiazole. Thiazoline is a liquid with a pyridine-like odor which was first isolated from mouse urine in 1977. Normally, there are three isomers of thiazolines: 2-thiazoline, 3-thiazoline and 4-thiazoline.
Thiazolidines have been applied as prodrug derivatives for various steroids containing a 3-carbonyl group to improve their topical anti-inflammatory activity. For example, thiazolidinones are saturated forms of thiazoles, which are thiazolidines bearing a carbonyl group. The 1,3-thiazolidin-4-ones possess wide range of pharmacological activities such as anti-cancer, anti-diabetic, anti-microbial, anti-viral, anti-inflammatory and anti-convulsant. Figure 1 summarizes various synthetic strategies for thiazolidinone derivatives and their biological significance. On the other hand, the structure of various pharmacologically active agents can be modified by using functional groups. With these functional group studies, prodrug strategies can be successfully applied to a wider range of drug molecules.
Figure 1. Various synthetic strategies for thiazolidinone derivatives as well as their biological significance[1].
Thiazolines are widely used in many fields as raw materials of various materials and pharmaceuticals. In organic synthesis, thiazoline can be used to synthesize 2-methyl-4-isothiazolin-3-one (MIT) preservatives, which can be added to cosmetics and detergents. In terms of drugs, benzisothiazolinone (BIT) has the advantages of broad antibacterial spectrum, high antibacterial activity, low toxicity, and environmental friendliness, and is expected to be an excellent agent for the prevention and treatment of tussah empty carcass disease.
If you are interested in our thiazoline/thiazolidine products, please contact us immediately!
References
Products
Customer Support
Twenty Four Seven
US&Canada
+1-844-BOC(262)-0123
UK
+1-631-504-6093
Ask a Question
Customer Centered
Global Delivery
Warehouses in multiple cities to ensure fast delivery
Free Support
Professional chemist team ready to solve your problem
Quality Assurance
Strict process parameter control to ensure product quality
Large Stock
> 20,000 building blocks and intermediates from stock
Customized Service
One-to-one custom synthesis for special structural needs
Process Scale-up
Process scale-up from lab to industrial scale
Global Sourcing
Low-cost global sourcing according to customer needs
Flexible Batch Size
Flexible batch size for diverse industrial demandsApplication Area
Medicinal chemistry and drug research require diverse chemical components to meet strict requirements not only in terms of physical and chemical properties but also in terms of chemical reactivity.
Medicinal chemistry and drug research require diverse chemical components to meet strict requirements not only in terms of physical and chemical properties but also in terms of chemical reactivity.
The chemists use the 'build–couple–pair' strategy of organic synthesis, which entails preparing molecular building blocks that contain several chemical groups.
The chemical building block (CBB) is a molecule which can be converted to various secondary chemicals and intermediates, and, in turn, into a broad range of different downstream uses.
Copyright © 2024 BOC Sciences. All rights reserved.
Our Products
