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Quinoline, also known as benzopyridine, is a compound in parallel with pyridine and benzene, and the molecular formula is C9H7N. Quinoline can also be regarded as a naphthaline-like nitrogen heterocyclic compound, that is, the nitrogen atom in the 1-position is replaced by the -CH group, so it is also known as azonaphthalene. The property of quinoline is similar to pyridine and naphthalene. The chemical synthesis of quinoline and its derivatives has attracted much attention from organic chemists and pharmaceutical chemists. In organic synthesis, there are theoretically three ways to form quinoline ring:
The structure of isoquinoline is similar to that of quinoline and the position of nitrogen atom is different. There are seventeen kinds of Isoquinolines according to structures like simple isoquinolines, protoberbeines, bis-benzyl isoquinolines, phthalein isoquinolines, spiracyl-phenyl isoquinolines. Isoquinoline compounds have a wide range of biological activities including antibacterial, anti-tumor, analgesic, regulating immune function, anti-platelet aggregation, anti-arrhythmia, antihypertensive.
Pharmaceutical Chemistry:
A large amount of quinoline compounds including isquinoline are important pharmaceutical intermediates, and many new drugs containing quinoline rings have been developed in recent years. Quinoline was originally obtained by distillation of quinine, an antimalarial drug. In recent years, quinoline drugs emerge in endlessly, such as quinophan can be used as antipyretic and analgesic drugs. Dibuvacaine hydrochloride can be used as a local anesthetic. Dequalinium chloride can be used as an antibiotic. Oxyquinoline phthalyl sulfathiazole can be synthesized from quinoline ring and other heterocyclic rings.
Fluorescent Material:
Acid dye yellow 3, direct yellow 22, solvent yellow 33 and Palanil yellow 3G can be synthesized with quinoline and quinoline derivatives. Quinoline anthocyanins are still important photosensitive substances in color photography, and the composition of quinoline rings in different quantities can make the sensitive region of light from ultraviolet to infrared or any one of them.
Food Industry:
Niacin is obtained by oxidation of quinoline. Niacin is an important vitamin that can synthesize a variety of nicotinic acid drugs, such as niacin, cardiac stimulants, and so on. In addition to synthesizing a variety of drugs, it is also widely used as a food and feed additive.
Organic Synthesis:
Most antioxidants containing quinoline rings are 1, 2-dihydroquinoline derivatives. A variety of 1, 2-dihydroquinoline derivatives have long been produced and can be used as an antioxidant, anti-aging agent in the rubber processing industry.
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Medicinal chemistry and drug research require diverse chemical components to meet strict requirements not only in terms of physical and chemical properties but also in terms of chemical reactivity.
Medicinal chemistry and drug research require diverse chemical components to meet strict requirements not only in terms of physical and chemical properties but also in terms of chemical reactivity.
The chemists use the 'build–couple–pair' strategy of organic synthesis, which entails preparing molecular building blocks that contain several chemical groups.
The chemical building block (CBB) is a molecule which can be converted to various secondary chemicals and intermediates, and, in turn, into a broad range of different downstream uses.
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