Products

Customer Support

Twenty Four Seven
US&Canada
+1-844-BOC(262)-0123
UK
+1-631-504-6093
Ask a Question

Customer Centered

Global Delivery

Warehouses in multiple cities to ensure fast delivery

Free Support

Professional chemist team ready to solve your problem

Quality Assurance

Strict process parameter control to ensure product quality

Large Stock

> 20,000 building blocks and intermediates from stock

Customized Service

One-to-one custom synthesis for special structural needs

Process Scale-up

Process scale-up from lab to industrial scale

Global Sourcing

Low-cost global sourcing according to customer needs

Flexible Batch Size

Flexible batch size for diverse industrial demands

Application Area

  • Medicinal Chemistry

    Medicinal Chemistry

    Medicinal chemistry and drug research require diverse chemical components to meet strict requirements not only in terms of physical and chemical properties but also in terms of chemical reactivity.

  • Organic Chemistry

    Organic Chemistry

    The chemists use the 'build–couple–pair' strategy of organic synthesis, which entails preparing molecular building blocks that contain several chemical groups.

  • Material chemistry

    Material chemistry

    The chemical building block (CBB) is a molecule which can be converted to various secondary chemicals and intermediates, and, in turn, into a broad range of different downstream uses.

Piperidines

  • Catalog: BB054204
  • Purity: 97.0%
  • Molecular Weight: 213.27
  • Molecular Formula: C11H19NO3
  • Catalog: BB054425
  • Purity: 97.0%
  • Molecular Weight: 213.275
  • Molecular Formula: C11H19NO3
  • Catalog: BB050358
  • Purity: 95%
  • Molecular Weight: 145.16
  • Molecular Formula: C6H11NO3
  • Catalog: BB042411
  • Purity: 95 %
  • Molecular Weight: 196.33
  • Molecular Formula: C12H24N2
  • Catalog: BB042413
  • Purity: 95 %
  • Molecular Weight: 181.62
  • Molecular Formula: C6H12ClNO3
  • Catalog: BB044312
  • Molecular Weight: 458.72
  • Molecular Formula: C29H50N2O2
  • Catalog: BB001840
  • Molecular Weight: 291.26
  • Molecular Formula: C14H24Cl2N2
  • Catalog: BB004698
  • Purity: > 95 %
  • Molecular Weight: 363.49
  • Molecular Formula: C24H29NO2
  • Catalog: BB001130
  • Molecular Weight: 401.97
  • Molecular Formula: C24H32ClNO2
  • Catalog: BB042365
  • Molecular Weight: 243.10
  • Molecular Formula: C8H11BrN4

Piperidines belong to a valuable category of heterocyclic compounds, which consist of a six membered nitrogen-containing ring and one secondary amine group. Piperidine derivatives are widely abundant in nature, numerous biologically active compounds contain the piperidines moiety as structural framework. Most piperidine analogs are obtained by complete hydrogenation reaction from the corelative pyridine. It is noteworthy that piperidine is flammable and highly stimulated, more importantly, piperidine is 1st catalogue precursor chemical and controlled drug, which is not allowed to be purchased without permission. Every care should be taken during its use and storage.

Piperidines Fig.1. Piperidine compounds

Unmodified piperidines are totally water-soluble, because the existence of unconjugated six-member rings and the nitrogen atom can form hydrogen bond with water molecule which coordinatively promote its solubility. Piperidine is a strong organic base with strong reducibility, all the piperidines possess secondary amine group as a major reaction site (red region in Fig 1). Their chemical properties are similar to that of aliphatic secondary amines, which can react with inorganic acids to produce corelative salts or participate in N-methylation to produce tertiary amines. Most piperidines are prepared by the hydrogenation of pyridine and piperidine compounds are the key active constituent parts of natural products, advancing the fabrication of various modern medicine and bioactive molecules.

Applications

Solvent:

Due to the presence of the polar secondary amine group, piperidine can be compatible with many polar substances. Besides, colorless piperidine contributes to the observation of reaction phenomena. Therefore, piperidines have been widely used in related fields, they are generally utilized as solvent for rubber, paints, varnishes, and as condensation agent to react with other electrophilic reagents.

Pharmaceutical Chemistry:

Piperidine compounds are widespread in biological products and psychogenic medicines. Their derivatives are usually used to fabricate potential medicine candidates, which possess remarkable pharmacological and physiological activities, such as antibacterial, anticonvulsant, anti-tumor and anti-inflammatory behavior, etc. The bioactivity and solubility of the piperidine derivatives can be adjusted by modifying different functional groups to achieve optimal effect (Fig 2).

Piperidines Fig.2. Representative psychiatric drugs with the piperidine framework
(Bioorganic & Medicinal Chemistry 2008, 16(2): 601-635.)

Agriculture:

Inspired by the antibacterial activity in medicinal precursors, piperidine derivatives can be applied as fungicides, insecticide, herbicide and so on. a variety of piperidine compounds are designed as intermediate for plant growth regulators for further commercial manufacture (Fig 3).

Piperidines Fig.3. Representative antibacterial chemicals with piperidine framework
(Helv. Chim. Acta 2012, 95, 1181-1197.)

Online Inquiry
Verification code

Phone

US & Canada (Toll free):

UK:

International:

E-mail & Fax

E-mail:

Fax:

 

Address

USA:

UK:

Inquiry Basket