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Application Area

  • Medicinal Chemistry

    Medicinal Chemistry

    Medicinal chemistry and drug research require diverse chemical components to meet strict requirements not only in terms of physical and chemical properties but also in terms of chemical reactivity.

  • Organic Chemistry

    Organic Chemistry

    The chemists use the 'build–couple–pair' strategy of organic synthesis, which entails preparing molecular building blocks that contain several chemical groups.

  • Material chemistry

    Material chemistry

    The chemical building block (CBB) is a molecule which can be converted to various secondary chemicals and intermediates, and, in turn, into a broad range of different downstream uses.


  • Catalog: BB042098
  • Molecular Weight: 125.15
  • Molecular Formula: C4H3N3S
  • Catalog: BB042094
  • Molecular Weight: 147.63
  • Molecular Formula: C5H6ClNS
  • Catalog: BB041979
  • Purity: > 98 %
  • Molecular Weight: 100.14
  • Molecular Formula: C3H4N2S
  • Catalog: BB041847
  • Purity: 95 %
  • Molecular Weight: 213.25
  • Molecular Formula: C9H11NO3S
  • Catalog: BB050558
  • Purity: 95 %
  • Molecular Weight: 221.21
  • Molecular Formula: C10H11N3O3
  • Catalog: BB049625
  • Purity: 95 %
  • Molecular Weight: 221.21
  • Molecular Formula: C10H11N3O3
  • Catalog: BB049630
  • Purity: 95 %
  • Molecular Weight: 207.19
  • Molecular Formula: C9H9N3O3
  • Catalog: BB049631
  • Purity: 95 %
  • Molecular Weight: 207.19
  • Molecular Formula: C9H9N3O3
  • Catalog: BB049623
  • Molecular Weight: 193.16
  • Molecular Formula: C8H7N3O3
  • Catalog: BB049629
  • Purity: 95 %
  • Molecular Weight: 193.16
  • Molecular Formula: C8H7N3O3


Oxazole and thiazole comprise an important type of aromatic heterocyclic compounds with a five-membered structure, which is a conjugated ring consisting three carbon atoms and one nitrogen atom, oxazole contains another oxygen atom while thiazole contains the sulfur atom (Fig 1). They are widely abundant in various natural substances, numerous biologically active compounds have been demonstrated that the oxazole or thiazole moiety is the major structural framework, offering potential application in medicinal synthesis. It is noteworthy that oxazole and thiazole exhibit a strong toxicity to organisms, they are flammable and will generate toxic smoke through combustion. So every care should be taken during their use and storage.

Oxazole/Thiazole Fig.1. Oxazole and thiazole compounds

Unmodified oxazole and thiazole are slightly water-soluble, because the polar five-membered rings bring stable conjugated structure and limit their dissolution, but the oxygen atom can form hydrogen bond with water molecule which slightly promote the solubility. Oxazole and thiazole possess relative low boiling point and melting point thus they are commonly presented as colorless liquid. Their chemical property is relatively stable and they are not easy to be reduced and react with nitric acid. However, thiazole can react with liquid bromine, sulfuric acid, acetic acid via electrophilic substitution reaction (Fig 2).


Pharmaceutical Chemistry:

Oxazole and thiazole compounds have been detected in various natural medicinal molecules, motivating the synthesis of artificial derivatives to fabricate biologic precursors, which possess excellent pharmacological and physiological activities, such as antibacterial, antidiabetic, antiparasitic, anti-tumor and anti-inflammatory behavior, etc. For example, Various alkaloids with thiazole motif have been fabricated (Fig 3).

Oxazole/Thiazole Fig.3. Chemical structure of antibacterial benzothiazole derivatives. (Prod. Rep. 2003, 20, 584-605.)


Inspired by the antibacterial activity in medicinal precursors, oxazole and thiazole derivatives can be applied as fungicides, insecticide, herbicide and so on. a variety of thiazole compounds are designed and characterized for further commercial manufacture.

Fluorescent Material:

It is well known that a larger conjugated constitution of compund will promote the red shift of the absorption to visible region, thus the color of the thiazole dye can be designed via expanding the degree of conjugation. Cyanine dye is a significant instance of thiazole dye fused with benzene ring, which can be classified as symmetric or asymmetric dyes according to the structure (Fig 4). Moreover, Cyanine dye can be utilized for intercalation and groove binding with DNA.

Oxazole/Thiazole Fig.4. Chemical structure of thiazole cyanine dyes. (Heterocycl. Commun. 2013, 19, 1-11.)

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