Products

Customer Support

Twenty Four Seven
US&Canada
+1-844-BOC(262)-0123
UK
+1-631-504-6093
Ask a Question

Customer Centered

Global Delivery

Warehouses in multiple cities to ensure fast delivery

Free Support

Professional chemist team ready to solve your problem

Quality Assurance

Strict process parameter control to ensure product quality

Large Stock

> 20,000 building blocks and intermediates from stock

Customized Service

One-to-one custom synthesis for special structural needs

Process Scale-up

Process scale-up from lab to industrial scale

Global Sourcing

Low-cost global sourcing according to customer needs

Flexible Batch Size

Flexible batch size for diverse industrial demands

Application Area

  • Medicinal Chemistry

    Medicinal Chemistry

    Medicinal chemistry and drug research require diverse chemical components to meet strict requirements not only in terms of physical and chemical properties but also in terms of chemical reactivity.

  • Organic Chemistry

    Organic Chemistry

    The chemists use the 'build–couple–pair' strategy of organic synthesis, which entails preparing molecular building blocks that contain several chemical groups.

  • Material chemistry

    Material chemistry

    The chemical building block (CBB) is a molecule which can be converted to various secondary chemicals and intermediates, and, in turn, into a broad range of different downstream uses.

Oxadiazole/Thiadiazole

  • Catalog: BB048176
  • Molecular Weight: 263.21
  • Molecular Formula: C11H9N3O5
  • Catalog: BB049541
  • Molecular Weight: 196.23
  • Molecular Formula: C7H8N4OS
  • Catalog: BB041896
  • Molecular Weight: 158.59
  • Molecular Formula: C6H7ClN2O
  • Catalog: BB048230
  • Purity: 97 %
  • Molecular Weight: 267.20
  • Molecular Formula: C9H9N5O5
  • Catalog: BB042471
  • Molecular Weight: 301.10
  • Molecular Formula: C9H9BrN4O3
  • Catalog: BB048193
  • Purity: 97 %
  • Molecular Weight: 267.20
  • Molecular Formula: C9H9N5O5
  • Catalog: BB052845
  • Molecular Weight: 348.1
  • Molecular Formula: C9H9IN4O3
  • Catalog: BB041460
  • Molecular Weight: 170.168
  • Molecular Formula: C7H10N2O3
  • Catalog: BB041299
  • Molecular Weight: 177.00
  • Molecular Formula: C4H5BrN2O
  • Catalog: BB041258
  • Purity: 95 %
  • Molecular Weight: 195.22
  • Molecular Formula: C8H6FN3S

Introduction

Oxadiazole and Thiadiazole are the sub-family of azole compounds, which are fairly common in a variety of pharmaceutical molecules. The molecular formula of Oxadiazoles is C2H2N2O, which can be synthesized with microwave method in moderate yields. There are four isomers of oxadiazole: 1,2,3-Oxadiazole, 1,2,4-Oxadiazole, 1,2,5-oxadiazole and 1,3,4-oxadiazole(Fig. 1), while the 1,2,3-isomer is not stale and readily decomposes to diazoketone tautomer via ring opening. Thiadiazole structurally are five-membered heterocyclic compounds containing two nitrogen and a sulfur atoms, and two double bonds, to give an aromatic ring. Four possible structures exist depending on the relative positions of the heteroatoms 1,2,3-thiadiazole, 1,2,4-thiadiazole, 1,2,5- thiadiazole, and 1,3,4-thiadiazole (Fig. 1) .

The structures of oxadiazole and thiadiazole isomers Fig. 1 The structures of oxadiazole and thiadiazole isomers

Application

Electron-transporting materials: Scientists have widely explored the applications of oxadiazole derivatives and found out it is suitable for electron-transporting, hole-blocking (ETHB) materials in electroluminescence devices due to their electron-deficient nature, their high thermal stability and high photoluminescence quantum yield (PLQY). The combination of oxadiazoles and pyridines or pyrimidines also has been studied for the bilayer devices.

Pharmaceutical Chemistry: It is well known in the literature that nitrogen and oxygen containing compounds are essentially used in medicine for the treatment of different kinds of fungal and bacterial infections along with the treatment of gastric ulcer, cancer, etc. In 2017, Modi group focused on 1,3,4-oxadiazoles and succeeded to synthesized a range of oxadiazoles derivatives via microwave activation, which afforded better yields compared to the conventional heating method. The compounds were screened later and behaved moderate to excellent microbial and cytotoxic activities. Besides, Spisani group discoved the oxadiazol-3-one derivative was revealed as a potent and selective myocardial calcium channel modulator. A 3D QSAR model (Fig 2)was obtained and validated with homologous literature data, and a virtual receptor scheme was derived for the unknown binding site. The following pharmacophoric features favorably affect the potency: one positively charged center, three lipophilic groups, and two hydrogen-bonding acceptor groups.

3D QSAR model and the structure of the oxadiazol-3-one Fig 2. 3D QSAR model and the structure of the oxadiazol-3-one

Some of the drug molecules that contain thiadiazole ring are sulfamethizole, acet-azolamide, cefazolin, xanomeline, timolol, and recently developed SCH-202676 (Fig.3). Thiadiazole are applied as bioisosteres of thiazole, oxazole, oxa-diazole, and benzene for the development of analogs with improved biological profiles. 1,2,4-Thiadiazoles and 1,3,4-thiadiazoles have been widely used by researchers due to their diverse chemical and biological potential.

Thiadiazole ring containing drugs Fig.3 Thiadiazole ring containing drugs

Optical Applications: Yang group have synthesized three new monomers containing 2,5-diphenyl-1,3,4-thiadiazole containing vinyl, and later carefully characterized their electrochemical and fluorescent properties., which can emit strong blue or green fluorescence have good solubility in CHCl3 or DMF. In addition, photoinduced intermolecular charge transfer, the key to photoluminescence, needed a molecular assembly containing electron-donor units and electron-accepting units as well as an intermolecular pi-conjugated structure. The aromatic 1,3,4- thiadiazole ring allows good pi-electron conjugation and was demonstrated as a good candidate for its electron-withdrawing property.

Electrochemistry: With phenyl units and 1,3,4-thiadiazole rings linked through acetylene groups, a π system extending throughout the molecular structure called a poly(aryl-ethynylene) (PAE) system was obtained. Polymers involving this system showed rather low intramolecular reorganization energies and can be considered as candidates for n-type semiconductors.

Referencs

  1. Electron-transporting materials for organic electroluminescent and electrophosphorescent devices. J. Mater. Chem., 2005, 15, 94-107
  2. Oxadiazole: Synthesis, characterization and biological activities. Journal of Saudi Chemical Society (2012) 16, 327–332
  3. A New Class of Selective Myocardial Calcium Channel Modulators. 2. Role of the Acetal Chain in Oxadiazol-3-one Derivatives. J. Med. Chem. 2005, 48, 2445-2456
  4. The synthesis, electrochemical and fluorescent properties of monomersand polymers containing 2,5-diphenyl-1,3,4-thiadiazole, Dyes and Pigments 84 (2010) 153–158
Online Inquiry
Verification code

Phone

US & Canada (Toll free):

UK:

International:

E-mail & Fax

E-mail:

Fax:

 

Address

USA:

UK:

Inquiry Basket