(Z)-7-((S)-2-Azido-2-carboxyethyl)thio Cilastatin Derivative

Catalog: BB075469
Product Name: (Z)-7-((S)-2-Azido-2-carboxyethyl)thio Cilastatin Derivative
Synonyms: (Z)-7-(((S)-2-Azido-2-carboxyethyl)thio)-2-((R)-2,2-dimethylcyclopropane-1-carboxamido)hept-2-enoic Acid
Description:(Z)-7-((S)-2-Azido-2-carboxyethyl)thio Cilastatin Derivative is an intermediate in the synthesis of (Z)-7-(((2R)-2-Carboxy-2-((4-oxopentan-2-yl)amino)ethyl)thio)-2-((S)-2,2-dimethylcyclopropanecarboxamido)hept-2-enoic Acid (C178930), an impurity of Cilastatin (C441100), prevents renal metabolism of penem and carbapenem antibiotics by specific and reversible dehydropeptidase I inhibition. Antibacterial adjunct.
Molecular Weight:384.45
Molecular Formula:C16H24N4O5S
Solubility:Dichloromethane
Appearance:Yellow syrup
Storage:-20°C
References:Finlay, K.R., et al. Invest. Ophthalmol. Visual Sci., 24, 1147 (1983), Norrby, S.R., et al. Antimicrob. Agents Chemother., 23, 300 (1983), Washburn, D.E., et al. J. Antimicrob. Chemother., 12, 39 (1983),.

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