Triethylene glycol monomethyl ether - CAS 112-35-6

Catalog:	BB002947
Product Name:	Triethylene glycol monomethyl ether
CAS:	112-35-6
Synonyms:	2-[2-(2-methoxyethoxy)ethoxy]ethanol
Application:	Activated PEG derivatives can be used to modify peptides, proteins, or in other bioconjugation applications. PEGylated materials have found broad use in drug delivery systems, virology, and immunology, as the incorporation of PEG improves pharmacological properties such as increased water solubility, enhanced resistance to degradation (protein hydrolysis), increased circulation half-life, and reduced antigenicity. In addition to PEGylation, activated PEG derivatives can also be used to form networks for tissue engineering or drug delivery applications, depending on the architecture and reactivity.

Technical Data

IUPAC Name:	2-[2-(2-methoxyethoxy)ethoxy]ethanol
Description:	Triethylene glycol monomethyl ether (CAS# 112-35-6) is a polymer which has been used in the synthesis of glycidyl triazolyl polymers.
Molecular Weight:	164.20
Molecular Formula:	C7H16O4
Canonical SMILES:	COCCOCCOCCO
InChI:	InChI=1S/C7H16O4/c1-9-4-5-11-7-6-10-3-2-8/h8H,2-7H2,1H3
InChI Key:	JLGLQAWTXXGVEM-UHFFFAOYSA-N
Boiling Point:	122 ℃ (10 mmHg)
Melting Point:	-44ºC
Flash Point:	118ºC
Purity:	purum, ≥97.0% (GC)
Density:	1.026 g/cm³
Solubility:	6.09 M;In water, miscible;Soluble in water;Solubility in heptane = 1.5 wt%, completely soluble in acetone, benzene, ethyl ether, methanol, and carbon tetrachloride at 25 °C.;Solubility in water: miscible
Appearance:	Viscous colorless liquid
Storage:	Inert atmosphere, Room Temperature
Decomposition:	When heated to decomposition it emits acrid smoke and irritating fumes
MDL:	MFCD00002875
LogP:	-0.34170
Quality Standard:	200
Refractive Index:	1.439
Vapor Pressure:	<0.01 mm Hg ( 20 °C)

GHS Hazard Statement:	H315 (97.44%): Causes skin irritation [Warning Skin corrosion/irritation]
Precautionary Statement:	P264, P280, P302+P352, P305+P351+P338, P321, P332+P313, P337+P313, and P362
Signal Word:	Warning

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PMID	Publication Date	Title	Journal
29570944	20180606	Anticancer Gold(III) Peptidomimetics: From Synthesis to in vitro and ex vivo Biological Evaluations	ChemMedChem
29205417	20180501	Inhibition of germinal vesicle breakdown in Xenopus oocytes in vitro by a series of substituted glycol ethers	Journal of applied toxicology : JAT
23008459	20121001	Severe poisoning after accidental pediatric ingestion of glycol ethers	Pediatrics
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Complexity:	67.5
Compound Is Canonicalized:	Yes
Covalently-Bonded Unit Count:	1
Defined Atom Stereocenter Count:	0
Defined Bond Stereocenter Count:	0
Exact Mass:	164.10485899
Formal Charge:	0
Heavy Atom Count:	11
Hydrogen Bond Acceptor Count:	4
Hydrogen Bond Donor Count:	1
Isotope Atom Count:	0
Monoisotopic Mass:	164.10485899
Rotatable Bond Count:	8
Topological Polar Surface Area:	47.9 Å²
Undefined Atom Stereocenter Count:	0
Undefined Bond Stereocenter Count:	0
XLogP3:	-1