trans-Ferulic acid - CAS 537-98-4
Catalog: |
BB028351 |
Product Name: |
trans-Ferulic acid |
CAS: |
537-98-4 |
Synonyms: |
(E)-3-(4-hydroxy-3-methoxyphenyl)prop-2-enoic acid |
Application: |
antioxidant |
IUPAC Name: | (E)-3-(4-hydroxy-3-methoxyphenyl)prop-2-enoic acid |
Description: | Trans-ferulic (FA) acid is a natural phenylpropanoid found in herbs of Euphorbia hylonoma, it exhibits antioxidant effects in vitro. Trans-ferulic has inhibitory effect on proliferation and migration of human lung cancer cells accompanied with increased endogenous reactive oxygen species and β-catenin instability. |
Molecular Weight: | 194.18 |
Molecular Formula: | C10H10O4 |
Canonical SMILES: | COC1=C(C=CC(=C1)C=CC(=O)O)O |
InChI: | InChI=1S/C10H10O4/c1-14-9-6-7(2-4-8(9)11)3-5-10(12)13/h2-6,11H,1H3,(H,12,13)/b5-3+ |
InChI Key: | KSEBMYQBYZTDHS-HWKANZROSA-N |
Boiling Point: | 372.3 °C at 760 mmHg |
Melting Point: | 168 - 171 °C |
Purity: | > 98 % |
Density: | 1.316 g/cm3 |
Appearance: | Powder |
LogP: | 1.49860 |
Quality Standard: | Enterprise Standard |
Vapor Pressure: | 0.00000269 [mmHg] |
GHS Hazard Statement: | H315 (100%): Causes skin irritation [Warning Skin corrosion/irritation] |
Precautionary Statement: | P261, P264, P271, P280, P302+P352, P304+P340, P305+P351+P338, P312, P321, P332+P313, P337+P313, P362, P403+P233, P405, and P501 |
Signal Word: | Warning |
Publication Number | Title | Priority Date |
CN-113456808-A | Composition, food or medicine containing superoxide dismutase and vitamin C | 20210902 |
CN-113499304-A | Exfoliating, brightening, skin-tendering and polishing scrub bath cream and preparation method thereof | 20210902 |
CN-113456794-A | Medicinal composition for removing obstruction in collaterals and removing blood stasis and preparation method thereof | 20210825 |
AU-2021105675-A4 | Treatment of by-products of plant industry | 20210816 |
CN-113425650-A | Oil control composition containing plant active ingredients | 20210816 |
PMID | Publication Date | Title | Journal |
33140555 | 20210301 | Ferulic acid alleviates lipopolysaccharide-induced acute lung injury through inhibiting TLR4/NF-κB signaling pathway | Journal of biochemical and molecular toxicology |
33428986 | 20210301 | Ferulic acid ameliorates the progression of pulmonary fibrosis via inhibition of TGF-β/smad signalling | Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association |
33045309 | 20201201 | Ferulic acid delayed amyloid β-induced pathological symptoms by autophagy pathway via a fasting-like effect in Caenorhabditis elegans | Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association |
32278740 | 20200601 | Gallic acid and ferulic acid protect the liver from thioacetamide-induced fibrosis in rats via differential expression of miR-21, miR-30 and miR-200 and impact on TGF-β1/Smad3 signaling | Chemico-biological interactions |
31584213 | 20200301 | Ferulic acid attenuates arsenic-induced cardiotoxicity in rats | Biotechnology and applied biochemistry |
Complexity: | 224 |
Compound Is Canonicalized: | Yes |
Covalently-Bonded Unit Count: | 1 |
Defined Atom Stereocenter Count: | 0 |
Defined Bond Stereocenter Count: | 1 |
Exact Mass: | 194.05790880 |
Formal Charge: | 0 |
Heavy Atom Count: | 14 |
Hydrogen Bond Acceptor Count: | 4 |
Hydrogen Bond Donor Count: | 2 |
Isotope Atom Count: | 0 |
Monoisotopic Mass: | 194.05790880 |
Rotatable Bond Count: | 3 |
Topological Polar Surface Area: | 66.8 Å2 |
Undefined Atom Stereocenter Count: | 0 |
Undefined Bond Stereocenter Count: | 0 |
XLogP3: | 1.5 |
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