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| Description: | Thiazol-5-ylmethyl ((2S,3S,5S)-5-Amino-3-((tert-butyldimethylsilyl)oxy)-1,6-diphenylhexan-2-yl)carbamate is an intermediate in synthesizing Bis(thiazol-5-yl-methyl)[carbonylbis[imino[(2S,3S,5S)-3-hydroxy-1,6-diphenylhexane-5,2-diyl]]]dicarbamate (R535035). Ritonavir Impurity P is derived from 2S,3S,5S-5-Amino-2-[N-[[(5-thiozolyl)methoxy]carbonyl]amino]-1,6-diphenyl-3-hydroxyhexane (A630525), which is an intermediate in the synthesis of Ritonavir (R535000), a selective HIV protease inhibitor. |
| Molecular Weight: | 539.8 |
| Molecular Formula: | C29H41N3O3SSi |
| Solubility: | Dichloromethane |
| Appearance: | Yellow Oil |
| References: | Kempf, D., et al. J. Med. Chem., 41, 602 (1998); Daluge, S., et al. Antimicrob. Agents Chemother., 38, 1590 (1994); Ammaranond, P., et al. J. Clin. Virol., 26, 153 (2003); Harrigan, P., et al. J. Infect. Dis., 191, 339 (2005); Miller, J., et al. Bioorg. Med. Chem. Lett., 16, 1788(2006). |
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