Tetraethylenepentamine pentahydrochloride - CAS 4961-41-5
Catalog: |
BB026754 |
Product Name: |
Tetraethylenepentamine pentahydrochloride |
CAS: |
4961-41-5 |
Synonyms: |
N1-(2-Aminoethyl)-N2-[2-[(2-aminoethyl)amino]ethyl]-1,2-ethanediamine Hydrochloride (1:5); 1,2-Ethanediamine, N1-(2-aminoethyl)-N2-[2-[(2-aminoethyl)amino]ethyl]-, hydrochloride (1:5); 1,2-Ethanediamine, N-(2-aminoethyl)-N'-[2-[(2-aminoethyl)amino]ethyl]-, pentahydrochloride; Tetraethylenepentamine hydrochloride; Tetraethylpentylamine pentahydrochloride; 1,11-Diamino-3,6,9-triazaundecane pentahydrochloride; 1,4,7,10,13-Pentaazatridecane pentahydrochloride; 3,6,9-Triaza-1,11-diaminoundecane pentahydrochloride |
Related CAS: | 112-57-2 (free base)
|
IUPAC Name: | N'-[2-[2-(2-aminoethylamino)ethylamino]ethyl]ethane-1,2-diamine;pentahydrochloride |
Description: | Tetraethylenepentamine pentahydrochloride (CAS# 4961-41-5) is used as a copper chelator, for the treatment of copper mobilization in copper-overloaded rats, and eventually for the as a therapy for disorders of copper transport, such as Wilson's disease. |
Molecular Weight: | 371.61 |
Molecular Formula: | C8H28Cl5N5 |
Canonical SMILES: | C(CNCCNCCNCCN)N.Cl.Cl.Cl.Cl.Cl |
InChI: | InChI=1S/C8H23N5.5ClH/c9-1-3-11-5-7-13-8-6-12-4-2-10;;;;;/h11-13H,1-10H2;5*1H |
InChI Key: | VGICAQBLDJAGSJ-UHFFFAOYSA-N |
Melting Point: | >250°C (dec.) |
Purity: | ≥95% |
Solubility: | Soluble in Aqueous Acid (Slightly), Methanol (Very Slightly), Water (Slightly) |
Appearance: | White to off-white powder |
Storage: | Store at -20°C |
MDL: | MFCD00083503 |
LogP: | 4.25590 |
GHS Hazard Statement: | H315 (100%): Causes skin irritation [Warning Skin corrosion/irritation] |
Precautionary Statement: | P261, P264, P271, P280, P302+P352, P304+P340, P305+P351+P338, P312, P321, P332+P313, P337+P313, P362, P403+P233, P405, and P501 |
Signal Word: | Warning |
Publication Number | Title | Priority Date |
WO-2021152584-A1 | Methods of analyzing cell membranes | 20200128 |
WO-2020257279-A1 | Combination treatments for central nervous system disorders | 20190617 |
US-2020131431-A1 | Chemical additives and surfactant combinations for favorable wettability alteration and improved hydrocarbon recovery factors | 20181026 |
WO-2020086309-A1 | Chemical additives and surfactant combinations for favorable wettability alteration and improved hydrocarbon recovery factors | 20181026 |
US-2018258029-A1 | Motuporamine derivatives as antimicrobial agents and antibiotic enhancers against resistant gram-negative bacteria | 20170109 |
PMID | Publication Date | Title | Journal |
25687434 | 20151101 | Featured Article: Hypoxia-inducible factor-1α dependent nuclear entry of factor inhibiting HIF-1 | Experimental biology and medicine (Maywood, N.J.) |
25240598 | 20150101 | Susceptibility of PTEN-positive metastatic tumors to small interfering RNA targeting the mammalian target of rapamycin | Nanomedicine : nanotechnology, biology, and medicine |
24593893 | 20140510 | Advanced cancer therapy by integrative antitumor actions via systemic administration of miR-499 | Journal of controlled release : official journal of the Controlled Release Society |
22770362 | 20120807 | Polyaspartamide derivative nanoparticles with tunable surface charge achieve highly efficient cellular uptake and low cytotoxicity | Langmuir : the ACS journal of surfaces and colloids |
22619252 | 20120801 | Copper is required for cobalt-induced transcriptional activity of hypoxia-inducible factor-1 | The Journal of pharmacology and experimental therapeutics |
Complexity: | 78.6 |
Compound Is Canonicalized: | Yes |
Covalently-Bonded Unit Count: | 6 |
Defined Atom Stereocenter Count: | 0 |
Defined Bond Stereocenter Count: | 0 |
Exact Mass: | 371.075784 |
Formal Charge: | 0 |
Heavy Atom Count: | 18 |
Hydrogen Bond Acceptor Count: | 5 |
Hydrogen Bond Donor Count: | 10 |
Isotope Atom Count: | 0 |
Monoisotopic Mass: | 369.078734 |
Rotatable Bond Count: | 10 |
Topological Polar Surface Area: | 88.1 Å2 |
Undefined Atom Stereocenter Count: | 0 |
Undefined Bond Stereocenter Count: | 0 |
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