![tert- Butyl 4- Bromo- 2- (1H- pyrrolo[2, 3- b] pyridin- 5- yloxy)benzoate](https://resource.bocsci.com/structure/1628047-84-6.gif)
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| IUPAC Name: | tert-butyl 4-bromo-2-(1H-pyrrolo[2,3-b]pyridin-5-yloxy)benzoate |
| Description: | tert- Butyl 4- Bromo- 2- (1H- pyrrolo[2, 3- b] pyridin- 5- yloxy)benzoate is used in the synthesis of apoptosis-inducing agents. Intermediate of Venetoclax (A112430), a potent and selective BCL-2 inhibitor that achieves potent antitumour activity while sparing platelets. |
| Molecular Weight: | 389.24 |
| Molecular Formula: | C18H17BrN2O3 |
| Canonical SMILES: | CC(C)(C)OC(=O)C1=C(C=C(C=C1)Br)OC2=CN=C3C(=C2)C=CN3 |
| InChI: | InChI=1S/C18H17BrN2O3/c1-18(2,3)24-17(22)14-5-4-12(19)9-15(14)23-13-8-11-6-7-20-16(11)21-10-13/h4-10H,1-3H3,(H,20,21) |
| InChI Key: | QTUZSJSEZUZNAS-UHFFFAOYSA-N |
| Melting Point: | 188 - 190°C |
| Solubility: | Chloroform (Slightly), DMSO (Slightly) |
| Appearance: | White to Off-White Solid |
| Storage: | -20°C, Inert atmosphere |
| References: | Davids, M. & Letai, A. Cancer Cell, 23, 139 (2013); Souers, A.,et al. Nat. Med., 19, 202 (2013); Vaillant, F., et al. Cancer Cell, 24, 120 (2013); Vogler, M., et al. Brit. J. Haematol., 163, 139 (2013). |
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