tert-Butyl 3-Bromo-6,7-dihydro-1H-pyrazolo[4,3-c]pyridine-5(4H)-carboxylate - CAS 1936429-06-9

Catalog: BB071066
Product Name: tert-Butyl 3-Bromo-6,7-dihydro-1H-pyrazolo[4,3-c]pyridine-5(4H)-carboxylate
CAS: 1936429-06-9
Synonyms: 1,1-Dimethylethyl 3-Bromo-1,4,6,7-tetrahydro-5H-pyrazolo[4,3-c]pyridine-5-carboxylate
tert-Butyl 3-Bromo-6,7-dihydro-1H-pyrazolo[4,3-c]pyridine-5(4H)-carboxylate
IUPAC Name:tert-butyl 3-bromo-1,4,6,7-tetrahydropyrazolo[4,3-c]pyridine-5-carboxylate
Description:tert-Butyl 3-Bromo-6,7-dihydro-1H-pyrazolo[4,3-c]pyridine-5(4H)-carboxylate is an intermediate in the synthesis of GNE-781 (D447825), a derivative of a highly advanced, potent and selective bromodomain inhibitor of cyclic adenosine monophosphate response element binding protein (CBP). Inhibition of the bromodomain of the transcriptional regulator CBP/P300 is an especially interesting new therapeutic approach in oncology.
Molecular Weight:302.17
Molecular Formula:C11H16BrN3O2
Canonical SMILES:CC(C)(C)OC(=O)N1CCC2=C(C1)C(=NN2)Br
InChI:InChI=1S/C11H16BrN3O2/c1-11(2,3)17-10(16)15-5-4-8-7(6-15)9(12)14-13-8/h4-6H2,1-3H3,(H,13,14)
InChI Key:CJOZZZFCHFPLJL-UHFFFAOYSA-N
Solubility:Dichloromethane
Appearance:Light Green Solid
References:Romero, F.A.; et al. J. Med. Chem, DOI: 10.1021/acs.jmedchem.7b00796 (2017).

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