![tert-Butyl 3-Bromo-1-(tetrahydro-2H-pyran-4-yl)-6,7-dihydro-1H-pyrazolo[4,3-c]pyridine-5(4H)-carboxylate](https://resource.bocsci.com/structure/1936429-15-0.gif)
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| IUPAC Name: | tert-butyl 3-bromo-1-(oxan-4-yl)-6,7-dihydro-4H-pyrazolo[4,3-c]pyridine-5-carboxylate |
| Description: | tert-Butyl 3-Bromo-1-(tetrahydro-2H-pyran-4-yl)-6,7-dihydro-1H-pyrazolo[4,3-c]pyridine-5(4H)-carboxylate is an intermediate in the synthesis of GNE-781 (D447825), a derivative of a highly advanced, potent and selective bromodomain inhibitor of cyclic adenosine monophosphate response element binding protein (CBP). Inhibition of the bromodomain of the transcriptional regulator CBP/P300 is an especially interesting new therapeutic approach in oncology. |
| Molecular Weight: | 386.28 |
| Molecular Formula: | C16H24BrN3O3 |
| Canonical SMILES: | CC(C)(C)OC(=O)N1CCC2=C(C1)C(=NN2C3CCOCC3)Br |
| InChI: | InChI=1S/C16H24BrN3O3/c1-16(2,3)23-15(21)19-7-4-13-12(10-19)14(17)18-20(13)11-5-8-22-9-6-11/h11H,4-10H2,1-3H3 |
| InChI Key: | KLNNZNTUBJKEBX-UHFFFAOYSA-N |
| Solubility: | Dichloromethane |
| Appearance: | Yellow Foam |
| References: | Romero, F.A.; et al. J. Med. Chem, DOI: 10.1021/acs.jmedchem.7b00796 (2017). |
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