tert-Butyl 3-Bromo-1-(tetrahydro-2H-pyran-4-yl)-6,7-dihydro-1H-pyrazolo[4,3-c]pyridine-5(4H)-carboxylate - CAS 1936429-15-0

Catalog: BB071182
Product Name: tert-Butyl 3-Bromo-1-(tetrahydro-2H-pyran-4-yl)-6,7-dihydro-1H-pyrazolo[4,3-c]pyridine-5(4H)-carboxylate
CAS: 1936429-15-0
Synonyms: 1,1-Dimethylethyl 3-Bromo-1,4,6,7-tetrahydro-1-(tetrahydro-2H-pyran-4-yl)-5H-pyrazolo[4,3-c]pyridine-5-carboxylate
tert-Butyl 3-Bromo-1-(tetrahydro-2H-pyran-4-yl)-6,7-dihydro-1H-pyrazolo[4,3-c]pyridine-5(4H)-carboxylate
IUPAC Name:tert-butyl 3-bromo-1-(oxan-4-yl)-6,7-dihydro-4H-pyrazolo[4,3-c]pyridine-5-carboxylate
Description:tert-Butyl 3-Bromo-1-(tetrahydro-2H-pyran-4-yl)-6,7-dihydro-1H-pyrazolo[4,3-c]pyridine-5(4H)-carboxylate is an intermediate in the synthesis of GNE-781 (D447825), a derivative of a highly advanced, potent and selective bromodomain inhibitor of cyclic adenosine monophosphate response element binding protein (CBP). Inhibition of the bromodomain of the transcriptional regulator CBP/P300 is an especially interesting new therapeutic approach in oncology.
Molecular Weight:386.28
Molecular Formula:C16H24BrN3O3
Canonical SMILES:CC(C)(C)OC(=O)N1CCC2=C(C1)C(=NN2C3CCOCC3)Br
InChI:InChI=1S/C16H24BrN3O3/c1-16(2,3)23-15(21)19-7-4-13-12(10-19)14(17)18-20(13)11-5-8-22-9-6-11/h11H,4-10H2,1-3H3
InChI Key:KLNNZNTUBJKEBX-UHFFFAOYSA-N
Solubility:Dichloromethane
Appearance:Yellow Foam
References:Romero, F.A.; et al. J. Med. Chem, DOI: 10.1021/acs.jmedchem.7b00796 (2017).

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