t-boc-N-amido-PEG2-alcohol - CAS 139115-91-6
Catalog: |
BB008894 |
Product Name: |
t-boc-N-amido-PEG2-alcohol |
CAS: |
139115-91-6 |
Synonyms: |
NHBoc-PEG2-OH; N-Boc-PEG2-alcohol; tert-Butyl (2-(2-hydroxyethoxy)ethyl)carbamate; 2-(2-Boc-aminoethoxy)ethanol; [2-(2-Hydroxyethoxy)ethyl]carbamic Acid 1,1-Dimethylethyl Ester; 2-(2-tert-Butoxycarbonylaminoethoxy)ethanol; N-Boc-2-aminoethyl 2-hydroxyethyl Ether; N-[2-(2-Hydroxyethoxy)ethyl]carbamic acid tert-butyl ester; Carbamic acid, N-[2-(2-hydroxyethoxy)ethyl]-, 1,1-dimethylethyl ester; Boc-NH-PEG2 |
Related CAS: | 159156-95-3 (polymer)
|
IUPAC Name: | tert-butyl N-[2-(2-hydroxyethoxy)ethyl]carbamate |
Description: | Boc-NH-PEG2 is a PROTAC linker, which refers to the alkyl/ether composition. Boc-NH-PEG2 can be used in the synthesis of a series of PROTACs. Boc-NH-PEG2 is a PEG derivative containing a hydroxyl group and Boc-protected amino group. The hydroxyl group enables further derivatization or replacement with other reactive functional groups. The Boc group can be deprotected under mild acidic conditions to form the free amine. |
Molecular Weight: | 205.25 |
Molecular Formula: | C9H19NO4 |
Canonical SMILES: | CC(C)(C)OC(=O)NCCOCCO |
InChI: | InChI=1S/C9H19NO4/c1-9(2,3)14-8(12)10-4-6-13-7-5-11/h11H,4-7H2,1-3H3,(H,10,12) |
InChI Key: | KSFVNEXYCULLEJ-UHFFFAOYSA-N |
Boiling Point: | 332.9±22.0°C (Predicted) |
Purity: | ≥95% |
Density: | 1.061 g/mL at 25°C |
Solubility: | Soluble in Chloroform (Slightly), DMSO (Slightly), Ethyl Acetate (Slightly), Methanol (Slightly) |
Appearance: | Colorless to Light Orange to Yellow Clear Liquid |
Storage: | Store at 2-8°C for short term (days to weeks) or -20°C for long term (months to years) |
LogP: | 0.91090 |
GHS Hazard Statement: | H301 (100%): Toxic if swallowed [Danger Acute toxicity, oral] |
Precautionary Statement: | P264, P270, P280, P301+P310, P302+P352, P305+P351+P338, P321, P330, P332+P313, P337+P313, P362, P405, and P501 |
Signal Word: | Danger |
Publication Number | Title | Priority Date |
WO-2021207291-A1 | Compounds and uses thereof | 20200406 |
KR-20210122708-A | HMG-CoA Reductase Degradation Inducing Compound | 20200330 |
WO-2021201577-A1 | Hmg-coa reductase degradation inducing compound | 20200330 |
KR-20210118297-A | p38 degrader compounds, method for preparing the same, and composition for treating chronic inflammatory diseases including the same | 20200320 |
WO-2021187766-A1 | Compound having p38 removal capability, preparation method therefor and composition for treating chronic inflammatory disease, comprising same | 20200320 |
PMID | Publication Date | Title | Journal |
21725302 | 20110703 | Small-molecule hydrophobic tagging-induced degradation of HaloTag fusion proteins | Nature chemical biology |
Complexity: | 165 |
Compound Is Canonicalized: | Yes |
Covalently-Bonded Unit Count: | 1 |
Defined Atom Stereocenter Count: | 0 |
Defined Bond Stereocenter Count: | 0 |
Exact Mass: | 205.13140809 |
Formal Charge: | 0 |
Heavy Atom Count: | 14 |
Hydrogen Bond Acceptor Count: | 4 |
Hydrogen Bond Donor Count: | 2 |
Isotope Atom Count: | 0 |
Monoisotopic Mass: | 205.13140809 |
Rotatable Bond Count: | 7 |
Topological Polar Surface Area: | 67.8 Å2 |
Undefined Atom Stereocenter Count: | 0 |
Undefined Bond Stereocenter Count: | 0 |
XLogP3: | 0.1 |
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