Suberohydroxamic acid - CAS 38937-66-5

Catalog:	BB023801
Product Name:	Suberohydroxamic acid
CAS:	38937-66-5
Synonyms:	N,N'-dihydroxyoctanediamide

Technical Data

Patents

Literatures

Computed Properties

IUPAC Name:	N,N'-dihydroxyoctanediamide
Description:	SBHA is a histone deacetylase (HDAC) inhibitor (ID50 = 0.25 and 0.3 μM for HDAC1 and HDAC3, respectively). SBHA can be used in combination with cytostatic drugs to enhance their effects against cancer cells.
Molecular Weight:	204.22
Molecular Formula:	C8H16N2O4
Canonical SMILES:	C(CCCC(=O)NO)CCC(=O)NO
InChI:	InChI=1S/C8H16N2O4/c11-7(9-13)5-3-1-2-4-6-8(12)10-14/h13-14H,1-6H2,(H,9,11)(H,10,12)
InChI Key:	IDQPVOFTURLJPT-UHFFFAOYSA-N
Melting Point:	154-156 ℃
Density:	1.158 g/cm³
Appearance:	White to light beige solid
MDL:	MFCD00192455
LogP:	1.11960

Publication Number	Title	Priority Date
US-2021259951-A1	Transmucosal Drug Delivery System	20200220
WO-2021167942-A1	Transmucosal drug delivery system	20200220
WO-2021081481-A1	Low dose adjuvant epigenetic cancer therapy	20191024
WO-2021060380-A1	Method for inducing hepatocyte plasticity	20190927
US-2021084896-A1	Broad-spectrum synergistic antimicrobial compositions	20190919

PMID	Publication Date	Title	Journal
33770205	20210501	Development and validation of the TGx-HDACi transcriptomic biomarker to detect histone deacetylase inhibitors in human TK6 cells	Archives of toxicology
22303878	20120901	Hyper-activation of WNT/β-catenin signaling pathway mediates anti-tumor effects of histone deacetylase inhibitors in acute T lymphoblastic leukemia	Leukemia & lymphoma
22075951	20120201	Combination therapy of conditionally replicating adenovirus and histone deacetylase inhibitors	International journal of molecular medicine
21675761	20110720	Nongenetic reprogramming of a fungal highly reducing polyketide synthase	Journal of the American Chemical Society
21627146	20110704	Complexes formed in solution between vanadium(IV)/(V) and the cyclic dihydroxamic acid putrebactin or linear suberodihydroxamic acid	Inorganic chemistry

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Related Functional Groups

Nitrogen Compounds

[89908-23-6]
2-Propenoic acid, 2-(3',3'-dimethyl-6-nitrospiro[2H-1-benzopyran-2,2'-[2H]indol]-1'(3'H)-yl)ethyl ester
[333311-69-6]
1-(4-Bromobenzyl)-3,5-dimethyl-4-nitro-1H-pyrazole
[865774-78-3]
2-(6,8-difluoro-1,2,3,4-tetrahydro-naphthalen-2-ylamino)-pentanoic acid methyl ester
[862649-86-3]
3-[(4-Chlorophenyl)sulfonyl]-5-nitrophenol
[1328640-72-7]
(1-Ethyl-3-nitro-1H-pyrazol-5-YL)methanol
[1002032-51-0]
1-(4-Chloro-1-ethyl-1H-pyrazol-5-yl)-N-methylmethanamine

Complexity:	164
Compound Is Canonicalized:	Yes
Covalently-Bonded Unit Count:	1
Defined Atom Stereocenter Count:	0
Defined Bond Stereocenter Count:	0
Exact Mass:	204.111007
Formal Charge:	0
Heavy Atom Count:	14
Hydrogen Bond Acceptor Count:	4
Hydrogen Bond Donor Count:	4
Isotope Atom Count:	0
Monoisotopic Mass:	204.111007
Rotatable Bond Count:	7
Topological Polar Surface Area:	98.7
Undefined Atom Stereocenter Count:	0
Undefined Bond Stereocenter Count:	0
XLogP3:	-0.5