rac Methotrimeprazine - CAS 851-68-3
Catalog: |
BB060206 |
Product Name: |
rac Methotrimeprazine |
CAS: |
851-68-3 |
Synonyms: |
10-[3-(Dimethylamino)-2-methylpropyl]-2-methoxyphenothiazine; (±)-2-Methoxy-10-[3-(dimethylamino)-2-methylpropyl]phenothiazine; (±)-Methotrimeprazine; 10-[3-(Dimethylamino)-2-methylpropyl]-2-methoxyphenothiazine; dl-Methotrimeprazine |
Related CAS: | 60-99-1
|
IUPAC Name: | 3-(2-methoxyphenothiazin-10-yl)-N,N,2-trimethylpropan-1-amine |
Description: | rac Methotrimeprazine is used as an analgesic agent. |
Molecular Weight: | 328.47 |
Molecular Formula: | C19H24N2OS |
Canonical SMILES: | CC(CN1C2=CC=CC=C2SC3=C1C=C(C=C3)OC)CN(C)C |
InChI: | InChI=1S/C19H24N2OS/c1-14(12-20(2)3)13-21-16-7-5-6-8-18(16)23-19-10-9-15(22-4)11-17(19)21/h5-11,14H,12-13H2,1-4H3 |
InChI Key: | VRQVVMDWGGWHTJ-UHFFFAOYSA-N |
Melting Point: | 99-102°C |
Solubility: | Chloroform (Slightly), DMSO (Slightly), Methanol (Slightly, Heated) |
Appearance: | Pale Beige to Brown Solid |
Storage: | Refrigerator |
References: | Viaud, et al. J. Pharm. and Pharmacol., 6, 361 (1954),. |
GHS Hazard Statement: | H302 (100%): Harmful if swallowed [Warning Acute toxicity, oral] |
Precautionary Statement: | P261, P264, P270, P271, P273, P280, P301+P317, P302+P352, P304+P340, P317, P321, P330, P332+P317, P362+P364, P391, and P501 |
Signal Word: | Warning |
Publication Number | Title | Priority Date |
WO-2019226080-A1 | A drug for treating disorders of an organ or tissue function and diseases accompanied by such disorders, and the method for obtaining it | 20180522 |
EP-3796936-A1 | A drug for treating disorders of an organ or tissue function and diseases accompanied by such disorders, and the method for obtaining it | 20180522 |
US-2021162047-A1 | A Drug For Treating Disorders Of An Organ Or Tissue Function And Diseases Accompanied By Such Disorders, And The Method For Obtaining It. | 20180522 |
CN-109562175-A | Pharmaceutical composition comprising the neutral carrier through energy process and relevant treatment method | 20160517 |
DE-112017002562-T5 | A pharmaceutical preparation containing an energized neutral carrier and related treatments | 20160517 |
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JP-2019518016-A | Pharmaceutical composition comprising a neutral carrier treated with energy, and related methods of treatment | 20160517 |
US-2017333560-A1 | Pharmaceutical Composition That Includes A Neutral Carrier Treated With Energy And Related Methods Of Treatment | 20160517 |
WO-2017199090-A1 | A pharmaceutical composition that includes a neutral carrier treated with energy and related methods of treatment | 20160517 |
WO-2017177240-A1 | Plant-based medicament for treatment for opiate addiction | 20160407 |
PMID | Publication Date | Title | Journal |
22859061 | 20121001 | Studies on photodegradation of levomepromazine and olanzapine under simulated environmental conditions | Photochemical & photobiological sciences : Official journal of the European Photochemistry Association and the European Society for Photobiology |
22718540 | 20120901 | Simultaneous determination of 25 common pharmaceuticals in whole blood using ultra-performance liquid chromatography-tandem mass spectrometry | Journal of analytical toxicology |
22918478 | 20120901 | A case of possible glossitis in a patient with non small cell carcinoma of the lung secondary to levomepromazine | Palliative medicine |
22114097 | 20120301 | Levomepromazine for schizophrenia | Schizophrenia bulletin |
22416830 | 20120301 | Recurrent delusional ideas due to left caudate head infarction, without dementia | Psychogeriatrics : the official journal of the Japanese Psychogeriatric Society |
21410738 | 20120201 | A stability indicating assay for a combination of morphine sulphate with levomepromazine hydrochloride used in palliative care | Journal of clinical pharmacy and therapeutics |
22109654 | 20120101 | Additional use of methotrimeprazine for treating refractory agitation in pediatric patients | Intensive care medicine |
22450639 | 20120101 | Levomepromazine-induced retrograde ejaculation | The Journal of neuropsychiatry and clinical neurosciences |
22860387 | 20120101 | Symptom management using methotrimeprazine: expanding the definition of respite sedation | Journal of palliative care |
21429493 | 20110506 | Quantitative determination of phenothiazine derivatives in human plasma using monolithic silica solid-phase extraction tips and gas chromatography-mass spectrometry | Journal of chromatography. A |
Complexity: | 378 |
Compound Is Canonicalized: | Yes |
Covalently-Bonded Unit Count: | 1 |
Defined Atom Stereocenter Count: | 0 |
Defined Bond Stereocenter Count: | 0 |
Exact Mass: | 328.16093457 |
Formal Charge: | 0 |
Heavy Atom Count: | 23 |
Hydrogen Bond Acceptor Count: | 4 |
Hydrogen Bond Donor Count: | 0 |
Isotope Atom Count: | 0 |
Monoisotopic Mass: | 328.16093457 |
Rotatable Bond Count: | 5 |
Topological Polar Surface Area: | 41Ų |
Undefined Atom Stereocenter Count: | 1 |
Undefined Bond Stereocenter Count: | 0 |
XLogP3: | 4.7 |
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