(R)-(-)-alpha-Methoxyphenylacetic Acid - CAS 3966-32-3
Catalog: |
BB024080 |
Product Name: |
(R)-(-)-alpha-Methoxyphenylacetic Acid |
CAS: |
3966-32-3 |
Synonyms: |
(2R)-2-methoxy-2-phenylacetic acid; (2R)-2-methoxy-2-phenylacetic acid |
IUPAC Name: | (2R)-2-methoxy-2-phenylacetic acid |
Description: | (R)-(-)-alpha-Methoxyphenylacetic Acid (CAS# 3966-32-3) is a useful synthetic intermediate. It is used as a reactant in the synthesis of dopamine receptor agonists. It can also be used to prepare hydroxytriamides as potent γ-secretase inhibitors. |
Molecular Weight: | 166.17 |
Molecular Formula: | C9H10O3 |
Canonical SMILES: | COC(C1=CC=CC=C1)C(=O)O |
InChI: | InChI=1S/C9H10O3/c1-12-8(9(10)11)7-5-3-2-4-6-7/h2-6,8H,1H3,(H,10,11)/t8-/m1/s1 |
InChI Key: | DIWVBIXQCNRCFE-MRVPVSSYSA-N |
Boiling Point: | 164-166 °C / 18 mmHg |
Melting Point: | 66-68 °C |
Purity: | 99 % |
Density: | 1.182 g/cm3 |
Appearance: | Powder or crystalline or crystalline powder |
Storage: | Room temperature. |
MDL: | MFCD00004250 |
LogP: | 1.45870 |
GHS Hazard Statement: | H315 (100%): Causes skin irritation [Warning Skin corrosion/irritation] |
Precautionary Statement: | P261, P264, P271, P280, P302+P352, P304+P340, P305+P351+P338, P312, P321, P332+P313, P337+P313, P362, P403+P233, P405, and P501 |
Signal Word: | Warning |
Publication Number | Title | Priority Date |
CN-111574328-A | Economical and practical resolution method of 2,2' -biphenol compound | 20200429 |
CN-111574450-A | Novel chiral biphenyl quaternary ammonium salt phase transfer catalyst and preparation method and application thereof | 20200429 |
WO-2021069927-A1 | Prostaglandin ep4 receptor antagonist compounds | 20191009 |
WO-2021026273-A1 | Scaleable preparation of polyketides | 20190806 |
WO-2021023209-A1 | Nitrogen-containing polycyclic fused ring compounds, and pharmaceutical composition thereof, preparation method therefor and application thereof | 20190805 |
PMID | Publication Date | Title | Journal |
21932062 | 20120501 | Enantioselective enzymatic hydrolysis of racemic drugs by encapsulation in sol-gel magnetic sporopollenin | Bioprocess and biosystems engineering |
22344605 | 20120401 | Evaluation of (R)-(-)-α-methoxy phenyl acetic acid as a chiral shift reagent for resolution and determination of R and S enantiomers of modafinil in bulk drugs and formulations by 1H NMR spectroscopy | Chirality |
12627454 | 20030301 | A glycopeptide antibiotic chiral stationary phase for the enantiomer resolution of hydroxy acid derivatives by capillary electrochromatography | Electrophoresis |
Complexity: | 150 |
Compound Is Canonicalized: | Yes |
Covalently-Bonded Unit Count: | 1 |
Defined Atom Stereocenter Count: | 1 |
Defined Bond Stereocenter Count: | 0 |
Exact Mass: | 166.062994177 |
Formal Charge: | 0 |
Heavy Atom Count: | 12 |
Hydrogen Bond Acceptor Count: | 3 |
Hydrogen Bond Donor Count: | 1 |
Isotope Atom Count: | 0 |
Monoisotopic Mass: | 166.062994177 |
Rotatable Bond Count: | 3 |
Topological Polar Surface Area: | 46.5 Å2 |
Undefined Atom Stereocenter Count: | 0 |
Undefined Bond Stereocenter Count: | 0 |
XLogP3: | 1.4 |
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