(R)-Diphenylprolinol - CAS 22348-32-9

Name: (R)-Diphenylprolinol
Brand: BOC Sciences
Rating: 5 (1 reviews)

Catalog:	BB017543
Product Name:	(R)-Diphenylprolinol
CAS:	22348-32-9
Synonyms:	R-(+)-Diphenylprolinol; (R)-(+)-2-(Diphenylhydroxymethyl)pyrrolidine; (R)-(+)-Diphenyl-2-pyrrolidinemethanol; (R)-(+)-α,α-Diphenyl-2-pyrrolidinemethanol; (R)-2-(Diphenylhydroxymethyl)pyrrolidine; (R)-Diphenyl(pyrrolidin-2-yl)methanol; (R)-α-(2-pyrrolidinyl)benzhydryl alcohol; 2-Pyrrolidinemethanol, α,α-diphenyl-, (2R)-
Application:	(R)-(+)-Diphenyl-2-pyrrolidinemethanol is Used to prepare the corresponding oxazaborolidines for the borane-mediated asymmetric reduction of ketones.

Technical Data

Related CAS:	172152-19-1 (hydrochloride)
IUPAC Name:	diphenyl-[(2R)-pyrrolidin-2-yl]methanol
Description:	(R)-Diphenylprolinol is the (R)-enantiomer of Diphenylprolinol, which is a norepinephrine-dopamine reuptake inhibitor used as a designer drug.
Molecular Weight:	253.35
Molecular Formula:	C17H19NO
Canonical SMILES:	C1CC(NC1)C(C2=CC=CC=C2)(C3=CC=CC=C3)O
InChI:	InChI=1S/C17H19NO/c19-17(16-12-7-13-18-16,14-8-3-1-4-9-14)15-10-5-2-6-11-15/h1-6,8-11,16,18-19H,7,12-13H2/t16-/m1/s1
InChI Key:	OGCGXUGBDJGFFY-MRXNPFEDSA-N
Boiling Point:	411.3±12.0°C at 760 mmHg
Melting Point:	77-80°C
Purity:	≥95%
Density:	1.1±0.1 g/cm3
Solubility:	Soluble in DMF, DMSO
Appearance:	White to Off-white Solid
Storage:	Store at RT
MDL:	MFCD00077754
LogP:	3.00330

GHS Hazard Statement:	H315 (100%): Causes skin irritation [Warning Skin corrosion/irritation]
Precautionary Statement:	P261, P264, P271, P280, P302+P352, P304+P340, P305+P351+P338, P312, P321, P332+P313, P337+P313, P362, P403+P233, P405, and P501
Signal Word:	Warning

Publication Number	Title	Priority Date
WO-2021083345-A1	Preparation method for pyrazolopyrimidine compound and intermediate thereof	20191030
US-2021171506-A1	Process for Manufacturing Pibrentasvir Active Drug Substance	20180829
WO-2020025748-A1	Process to make a selective cathepsin cysteine protease inhibitor	20180802
US-10654866-B2	Selective estrogen receptor degraders	20180712
US-2020347073-A1	Selective estrogen receptor degraders	20180712

Complexity:	261
Compound Is Canonicalized:	Yes
Covalently-Bonded Unit Count:	1
Defined Atom Stereocenter Count:	1
Defined Bond Stereocenter Count:	0
Exact Mass:	253.146664230
Formal Charge:	0
Heavy Atom Count:	19
Hydrogen Bond Acceptor Count:	2
Hydrogen Bond Donor Count:	2
Isotope Atom Count:	0
Monoisotopic Mass:	253.146664230
Rotatable Bond Count:	3
Topological Polar Surface Area:	32.3 Å²
Undefined Atom Stereocenter Count:	0
Undefined Bond Stereocenter Count:	0
XLogP3:	2.7