(R)-5-[2-(2,5-Difluorophenyl)-1-pyrrolidinyl]pyrazolo[1,5-a]pyrimidin-3-amine - CAS 1223404-88-3

Name: (R)-5-[2-(2,5-Difluorophenyl)-1-pyrrolidinyl]pyrazolo[1,5-a]pyrimidin-3-amine
Brand: BOC Sciences
Rating: 5 (1 reviews)

Catalog:	BB005392
Product Name:	(R)-5-[2-(2,5-Difluorophenyl)-1-pyrrolidinyl]pyrazolo[1,5-a]pyrimidin-3-amine
CAS:	1223404-88-3
Synonyms:	5-[(2R)-2-(2,5-difluorophenyl)-1-pyrrolidinyl]-3-pyrazolo[1,5-a]pyrimidinamine; 5-[(2R)-2-(2,5-difluorophenyl)pyrrolidin-1-yl]pyrazolo[1,5-a]pyrimidin-3-amine

Technical Data

IUPAC Name:	5-[(2R)-2-(2,5-difluorophenyl)pyrrolidin-1-yl]pyrazolo[1,5-a]pyrimidin-3-amine
Description:	(R)-5-[2-(2,5-Difluorophenyl)-1-pyrrolidinyl]pyrazolo[1,5-a]pyrimidin-3-amine (CAS# 1223404-88-3 ) is a useful research chemical.
Molecular Weight:	315.32
Molecular Formula:	C16H15F2N5
Canonical SMILES:	C1CC(N(C1)C2=NC3=C(C=NN3C=C2)N)C4=C(C=CC(=C4)F)F
InChI:	InChI=1S/C16H15F2N5/c17-10-3-4-12(18)11(8-10)14-2-1-6-22(14)15-5-7-23-16(21-15)13(19)9-20-23/h3-5,7-9,14H,1-2,6,19H2/t14-/m1/s1
InChI Key:	PNTNLXBVYHOZQI-CQSZACIVSA-N
Storage:	Keep in dark place, Sealed in dry, 2-8 °C
LogP:	3.57740

Publication Number	Title	Priority Date
WO-2021110081-A1	Substituted pyrazolo[1,5-a]pyrimidine amino acid derivative and use thereof	20191204
WO-2021042890-A1	Heterocyclic compound and application thereof as trk kinase inhibitor	20190904
WO-2020135203-A1	Pharmaceutical compound, composition thereof, and application	20181225
WO-2019029629-A1	SUBSTITUTED PYRAZOLOPYRIMIDINES FOR USE AS KINASE INHIBITORS	20170811
EP-3458456-A1	Preparation of (s)-n-(5-((r)-2-(2,5-difluorophenyl)pyrrolidin-1-yl)pyrazolo[1,5-a]pyrimidin-3-y l)-3-hydroxypyrrolidine-1-carboxamide	20160518

Complexity:	425
Compound Is Canonicalized:	Yes
Covalently-Bonded Unit Count:	1
Defined Atom Stereocenter Count:	1
Defined Bond Stereocenter Count:	0
Exact Mass:	315.12955182
Formal Charge:	0
Heavy Atom Count:	23
Hydrogen Bond Acceptor Count:	6
Hydrogen Bond Donor Count:	1
Isotope Atom Count:	0
Monoisotopic Mass:	315.12955182
Rotatable Bond Count:	2
Topological Polar Surface Area:	59.4
Undefined Atom Stereocenter Count:	0
Undefined Bond Stereocenter Count:	0
XLogP3:	2.3