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| Related CAS: | 1869912-40-2 |
| IUPAC Name: | (3R)-4-[2-[4-[1-(3-methoxy-[1,2,4]triazolo[4,3-b]pyridazin-6-yl)piperidin-4-yl]phenoxy]ethyl]-1,3-dimethylpiperazin-2-one |
| Description: | AZD5153 is a potent, selective, and orally available inhibitor of the bromodomain and extraterminal (BET) Inhibitor. It can simultaneously bind two bromodomains in BRD4 with the IC50 value of 5 nM, which has been shown to increase antitumor activity in multiple xenograft models of acute myeloid leukemia, multiple myeloma, and diffuse large B cell lymphoma. AZD5153 also shows enhanced potency as a result of bivalent binding and a clear correlation between BRD4 activity and cellular potency. |
| Molecular Weight: | 479.57 |
| Molecular Formula: | C25H33N7O3 |
| Canonical SMILES: | CC1C(=O)N(CCN1CCOC2=CC=C(C=C2)C3CCN(CC3)C4=NN5C(=NN=C5OC)C=C4)C |
| InChI: | InChI=1S/C25H33N7O3/c1-18-24(33)29(2)14-15-30(18)16-17-35-21-6-4-19(5-7-21)20-10-12-31(13-11-20)23-9-8-22-26-27-25(34-3)32(22)28-23/h4-9,18,20H,10-17H2,1-3H3/t18-/m1/s1 |
| InChI Key: | RSMYFSPOTCDHHJ-GOSISDBHSA-N |
| Purity: | ≥ 95 % |
| Solubility: | Soluble to ≤20 mg/ml in ethanol, to 20 mg/ml in DMSO. |
| Appearance: | Crystalline solid |
| LogP: | 1.99900 |
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