D-α-Hydroxyglutaric acid - CAS 13095-47-1

Catalog: BB007204
Product Name: D-α-Hydroxyglutaric acid
CAS: 13095-47-1
Synonyms: (R)-2-Hydroxyglutarate; (R)-2-Hydroxyglutaric acid; (R)-2-Hydroxypentanedioic acid; D-2-Hydroxyglutaric acid
D-α-Hydroxyglutaric acid
IUPAC Name:(2R)-2-hydroxypentanedioic acid
Description:D-α-Hydroxyglutaric acid is the principal metabolite accumulating in neurometabolic disease D-2-hydroxyglutaric aciduria. D-α-Hydroxyglutaric acid is a weak competitive antagonist of α-ketoglutarate (α-KG) and inhibits multiple α-KG-dependent dioxygenases with a Ki of 10.87 mM. D-α-Hydroxyglutaric acid binds and inhibits ATP synthase and inhibits mTOR signaling.
Molecular Weight:148.11
Molecular Formula:C5H8O5
Canonical SMILES:C(CC(=O)O)C(C(=O)O)O
InChI:InChI=1S/C5H8O5/c6-3(5(9)10)1-2-4(7)8/h3,6H,1-2H2,(H,7,8)(H,9,10)/t3-/m1/s1
InChI Key:HWXBTNAVRSUOJR-GSVOUGTGSA-N
Melting Point:> 300 °C
Appearance:Solid
LogP:-0.70330

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