(R)-1-Boc-3-hydroxypiperidine - CAS 143900-43-0

Name: (R)-1-Boc-3-hydroxypiperidine
Brand: BOC Sciences
Rating: 5 (1 reviews)

Catalog:	BB009686
Product Name:	(R)-1-Boc-3-hydroxypiperidine
CAS:	143900-43-0
Synonyms:	1-Piperidinecarboxylic acid, 3-hydroxy-, 1,1-dimethylethyl ester, (3R)-; 1,1-Dimethylethyl (3R)-3-hydroxy-1-piperidinecarboxylate; 1-Piperidinecarboxylic acid, 3-hydroxy-, 1,1-dimethylethyl ester, (R)-; (3R)-3-Hydroxypiperidine-1-carboxylic acid tert-butyl ester; (R)-3-Hydroxy-1-(tert-butoxycarbonyl)piperidine; (R)-3-Hydroxypiperidine-1-carboxylic acid tert-butyl ester; (R)-tert-Butyl 3-hydroxy-1-piperidinecarboxylate; (R)-tert-Butyl 3-hydroxypiperidine-1-carboxylate; N-Boc-3R-hydroxypiperidine; tert-Butyl (R)-3-hydroxypiperidine-1-carboxylate

Technical Data

IUPAC Name:	tert-butyl (3R)-3-hydroxypiperidine-1-carboxylate
Description:	(R)-1-Boc-3-hydroxypiperidine has been used as a reactant for the synthesis of piperidinyl and pyrrolidinyl butyrates. (R)-1-Boc-3-hydroxypiperidine has also been used for the synthesis of constrained (-)-S-adenosyl-L-homocysteine (SAH) analogs as DNA methyltransferase inhibitors.
Molecular Weight:	201.26
Molecular Formula:	C10H19NO3
Canonical SMILES:	CC(C)(C)OC(=O)N1CCCC(C1)O
InChI:	InChI=1S/C10H19NO3/c1-10(2,3)14-9(13)11-6-4-5-8(12)7-11/h8,12H,4-7H2,1-3H3/t8-/m1/s1
InChI Key:	UIJXHKXIOCDSEB-MRVPVSSYSA-N
Boiling Point:	292.3±33.0°C at 760 mmHg
Melting Point:	49-53°C
Purity:	≥95%
Density:	1.107±0.06 g/cm3
Solubility:	Soluble in Chloroform (Sparingly), DMSO (Slightly), Ethyl Acetate (Sparingly)
Appearance:	White to Off-white Solid
Storage:	Store at 2-8°C
MDL:	MFCD04115306
LogP:	1.31610

GHS Hazard Statement:	H301 (95.83%): Toxic if swallowed [Danger Acute toxicity, oral]
Precautionary Statement:	P261, P264, P270, P271, P280, P301+P310, P302+P352, P304+P340, P305+P351+P338, P310, P312, P321, P330, P332+P313, P362, P403+P233, P405, and P501
Signal Word:	Danger

Publication Number	Title	Priority Date
CN-112251478-A	Ketoreductase and enzyme catalysis preparation method of S-1-BOC-3 hydroxypiperidine	20201026
CN-113072521-A	ROR gamma t inhibitor and application thereof in medicine	20200106
CN-113122050-A	Quantum dot ink and preparation method of quantum dot film	20191230
KR-20210081285-A	Novel Amide Derivatives and Their Use as Inhibitors against Diacylglycerol Acyltransferase 2	20191223
KR-20210081286-A	Novel Amino Aryl Derivatives and Their Use as Inhibitors against Diacylglycerol Acyltransferase 2	20191223

Complexity:	210
Compound Is Canonicalized:	Yes
Covalently-Bonded Unit Count:	1
Defined Atom Stereocenter Count:	1
Defined Bond Stereocenter Count:	0
Exact Mass:	201.13649347
Formal Charge:	0
Heavy Atom Count:	14
Hydrogen Bond Acceptor Count:	3
Hydrogen Bond Donor Count:	1
Isotope Atom Count:	0
Monoisotopic Mass:	201.13649347
Rotatable Bond Count:	2
Topological Polar Surface Area:	49.8 Å²
Undefined Atom Stereocenter Count:	0
Undefined Bond Stereocenter Count:	0
XLogP3:	1