(R)-(-)-1-Aminoindane - CAS 10277-74-4

Name: (R)-(-)-1-Aminoindane
Brand: BOC Sciences
Rating: 5 (1 reviews)

Catalog:	BB000946
Product Name:	(R)-(-)-1-Aminoindane
CAS:	10277-74-4
Synonyms:	(1R)-2,3-dihydro-1H-inden-1-amine; (1R)-2,3-dihydro-1H-inden-1-amine

Technical Data

IUPAC Name:	(1R)-2,3-dihydro-1H-inden-1-amine
Description:	An intermediate for Rasagiline Mesylate.Rasagiline is an irreversible inhibitor of monoamine oxidase-B. It can be used as a monotherapy to treat symptoms in early Parkinson's disease or as an adjunct therapy in more advanced cases.
Molecular Weight:	133.19
Molecular Formula:	C9H11N
Canonical SMILES:	C1CC2=CC=CC=C2C1N
InChI:	InChI=1S/C9H11N/c10-9-6-5-7-3-1-2-4-8(7)9/h1-4,9H,5-6,10H2/t9-/m1/s1
InChI Key:	XJEVHMGJSYVQBQ-SECBINFHSA-N
Boiling Point:	96 °C (8 mmHg)
Purity:	> 95 %
Density:	1.038 g/cm³
Appearance:	Clear brown to dark brown oil
MDL:	MFCD00216669
LogP:	2.33290

GHS Hazard Statement:	H315 (100%): Causes skin irritation [Warning Skin corrosion/irritation]
Precautionary Statement:	P261, P264, P271, P273, P280, P302+P352, P304+P340, P305+P351+P338, P312, P321, P332+P313, P337+P313, P362, P391, P403+P233, P405, and P501
Signal Word:	Warning

Publication Number	Title	Priority Date
CN-112280761-A	Recombinant transaminase, mutant of recombinant transaminase and application of mutant	20201116
CN-113030283-A	Rasagiline genotoxic impurity compound and preparation method and application thereof	20191225
WO-2020221209-A1	Cd73 inhibitor, preparation method therefor and application thereof	20190428
CN-113366008-A	CD73 inhibitor, preparation method and application thereof	20190428
TW-202106311-A	A CD73 inhibitor, its preparation method and application	20190428

PMID	Publication Date	Title	Journal
22761132	20120701	Chiral amines as reagents for HPLC-MS enantioseparation of chiral carboxylic acids	Journal of separation science
20919927	20110301	Does 1-(R)-aminoindan possess neuroprotective properties against experimental Parkinson's disease?	Antioxidants & redox signaling
21338509	20110221	Effects of rasagiline, its metabolite aminoindan and selegiline on glutamate receptor mediated signalling in the rat hippocampus slice in vitro	BMC pharmacology
20600573	20101101	Rasagiline: a novel anti-Parkinsonian monoamine oxidase-B inhibitor with neuroprotective activity	Progress in neurobiology
20002521	20100301	The neuroprotective mechanism of 1-(R)-aminoindan, the major metabolite of the anti-parkinsonian drug rasagiline	Journal of neurochemistry

Complexity:	122
Compound Is Canonicalized:	Yes
Covalently-Bonded Unit Count:	1
Defined Atom Stereocenter Count:	1
Defined Bond Stereocenter Count:	0
Exact Mass:	133.089149355
Formal Charge:	0
Heavy Atom Count:	10
Hydrogen Bond Acceptor Count:	1
Hydrogen Bond Donor Count:	1
Isotope Atom Count:	0
Monoisotopic Mass:	133.089149355
Rotatable Bond Count:	0
Topological Polar Surface Area:	26 Å²
Undefined Atom Stereocenter Count:	0
Undefined Bond Stereocenter Count:	0
XLogP3:	1.2