N,N'-Dimethylhydrazine dihydrochloride - CAS 306-37-6
Catalog: |
BB020664 |
Product Name: |
N,N'-Dimethylhydrazine dihydrochloride |
CAS: |
306-37-6 |
Synonyms: |
1,2-dimethylhydrazine;dihydrochloride |
IUPAC Name: | 1,2-dimethylhydrazine;dihydrochloride |
Description: | N,N'-Dimethylhydrazine dihydrochloride (CAS# 306-37-6) is a potent carcinogen that acts as a DNA alkylating agent. It is used to induce colon tumors in experimental animals. It was also used in preparation of spiroisoquinolinedione aldose reductase inhibitors. |
Molecular Weight: | 133.02 |
Molecular Formula: | C2H10Cl2N2 |
Canonical SMILES: | CNNC.Cl.Cl |
InChI: | InChI=1S/C2H8N2.2ClH/c1-3-4-2;;/h3-4H,1-2H3;2*1H |
InChI Key: | WLDRFJDGKMTPPV-UHFFFAOYSA-N |
Boiling Point: | 81.5 °C at 760 mmHg |
Melting Point: | 333 to 336 °F (decomposes) |
Density: | 0.759 g/cm3 |
Solubility: | greater than or equal to 100 mg/mL at 73 °F |
Appearance: | White to light yellow flakes |
MDL: | MFCD00012522 |
LogP: | 1.72600 |
GHS Hazard Statement: | H301 (100%): Toxic if swallowed [Danger Acute toxicity, oral]; H311 (97.44%): Toxic in contact with skin [Danger Acute toxicity, dermal]; H331 (97.44%): Toxic if inhaled [Danger Acute toxicity, inhalation]; H350 (97.44%): May cause cancer [Danger Carcinogenicity] |
Precautionary Statement: | P203, P261, P264, P270, P271, P280, P301+P316, P302+P352, P304+P340, P316, P318, P321, P330, P361+P364, P403+P233, P405, and P501 |
Signal Word: | Danger |
Publication Number | Title | Priority Date |
CN-111807993-A | Near-infrared fluorescent compound for specifically detecting hydrazine and preparation method thereof | 20200722 |
WO-2021188696-A1 | Stat degraders and uses thereof | 20200317 |
TW-202003525-A | New heterocyclic compounds | 20180322 |
WO-2019180185-A1 | Oxazine monoacylglycerol lipase (magl) inhibitors | 20180322 |
AU-2019238381-A1 | Oxazine monoacylglycerol lipase (MAGL) inhibitors | 20180322 |
PMID | Publication Date | Title | Journal |
22441428 | 20121101 | Dolastatin 15, a mollusk linear peptide, and Celecoxib, a selective cyclooxygenase-2 inhibitor, prevent preneoplastic colonic lesions and induce apoptosis through inhibition of the regulatory transcription factor NF-κB and an inflammatory protein, iNOS | European journal of cancer prevention : the official journal of the European Cancer Prevention Organisation (ECP) |
22397759 | 20120701 | Role of Sulindac and Celecoxib in the regulation of angiogenesis during the early neoplasm of colon: exploring PI3-K/PTEN/Akt pathway to the canonical Wnt/β-catenin signaling | Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie |
22369161 | 20120401 | Piroxicam and C-phycocyanin mediated apoptosis in 1,2-dimethylhydrazine dihydrochloride induced colon carcinogenesis: exploring the mitochondrial pathway | Nutrition and cancer |
21946862 | 20120301 | Chemopreventive effect of different ratios of fish oil and corn oil on prognostic markers, DNA damage and cell cycle in colon carcinogenesis | European journal of cancer prevention : the official journal of the European Cancer Prevention Organisation (ECP) |
22519408 | 20120101 | Ras signaling pathway in the chemopreventive action of different ratios of fish oil and corn oil in experimentally induced colon carcinogenesis | Nutrition and cancer |
Complexity: | 6 |
Compound Is Canonicalized: | Yes |
Covalently-Bonded Unit Count: | 3 |
Defined Atom Stereocenter Count: | 0 |
Defined Bond Stereocenter Count: | 0 |
Exact Mass: | 132.0221037 |
Formal Charge: | 0 |
Heavy Atom Count: | 6 |
Hydrogen Bond Acceptor Count: | 2 |
Hydrogen Bond Donor Count: | 4 |
Isotope Atom Count: | 0 |
Monoisotopic Mass: | 132.0221037 |
Rotatable Bond Count: | 1 |
Topological Polar Surface Area: | 24.1 |
Undefined Atom Stereocenter Count: | 0 |
Undefined Bond Stereocenter Count: | 0 |
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