N-Dodecylimidazole - CAS 4303-67-7
Catalog: |
BB025306 |
Product Name: |
N-Dodecylimidazole |
CAS: |
4303-67-7 |
Synonyms: |
1-Dodecyl-1H-imidazole; 1-Laurylimidazole; N-Laurylimidazole; NSC 307267 |
IUPAC Name: | 1-dodecylimidazole |
Description: | N-Dodecylimidazole is a lysosomotropic detergent and cytotoxic agent with hypocholesterolaemic activity and broad-spectrum antifungal activity. It causes cell death by its acid-dependent accumulation in lysosomes, destroys the lysosomal membrane, and releases cysteine proteases into the cytoplasm. |
Molecular Weight: | 236.40 |
Molecular Formula: | C15H28N2 |
Canonical SMILES: | CCCCCCCCCCCCN1C=CN=C1 |
InChI: | InChI=1S/C15H28N2/c1-2-3-4-5-6-7-8-9-10-11-13-17-14-12-16-15-17/h12,14-15H,2-11,13H2,1H3 |
InChI Key: | JMTFLSQHQSFNTE-UHFFFAOYSA-N |
Boiling Point: | 364.2±11.0°C at 760 mmHg |
Melting Point: | 69.5-70.5°C |
Purity: | ≥95% |
Density: | 0.9±0.1 g/cm3 |
Solubility: | Soluble in Chloroform (Slightly), Methanol (Slightly) |
Appearance: | Colorless Oily Matter |
Storage: | Store at 2-8°C |
LogP: | 4.80400 |
GHS Hazard Statement: | H302 (98.9%): Harmful if swallowed [Warning Acute toxicity, oral] |
Precautionary Statement: | P261, P264, P270, P272, P273, P280, P301+P312, P302+P352, P305+P351+P338, P321, P330, P333+P313, P337+P313, P363, P391, and P501 |
Signal Word: | Warning |
Publication Number | Title | Priority Date |
JP-2021152083-A | Pest control method | 20210702 |
JP-2021152084-A | Pest control method | 20210702 |
JP-2021152085-A | Pest control method | 20210702 |
JP-2021138753-A | Pest control method for harmful arthropods using heterocyclic compounds | 20210610 |
JP-2021102661-A | Pest control composition and control method | 20210416 |
PMID | Publication Date | Title | Journal |
14562034 | 20031020 | Cathepsin-B and cathepsin-L expression levels do not correlate with sensitivity of tumour cells to TNF-alpha-mediated apoptosis | British journal of cancer |
14611845 | 20030901 | Synthesis of N-alkylated derivatives of imidazole as antibacterial agents | Bioorganic & medicinal chemistry letters |
12659955 | 20030401 | Cytosolic delivery of macromolecules: I. Synthesis and characterization of pH-sensitive acyloxyalkylimidazoles | Biochimica et biophysica acta |
12561319 | 20021202 | Self-organized lipid-porphyrin bilayer membranes in vesicular form: nanostructure, photophysical properties, and dioxygen coordination | Chemistry (Weinheim an der Bergstrasse, Germany) |
3302260 | 19870801 | Lysosomotropic agents. 7. Broad-spectrum antifungal activity of lysosomotropic detergents | Journal of medicinal chemistry |
Complexity: | 159 |
Compound Is Canonicalized: | Yes |
Covalently-Bonded Unit Count: | 1 |
Defined Atom Stereocenter Count: | 0 |
Defined Bond Stereocenter Count: | 0 |
Exact Mass: | 236.225248902 |
Formal Charge: | 0 |
Heavy Atom Count: | 17 |
Hydrogen Bond Acceptor Count: | 1 |
Hydrogen Bond Donor Count: | 0 |
Isotope Atom Count: | 0 |
Monoisotopic Mass: | 236.225248902 |
Rotatable Bond Count: | 11 |
Topological Polar Surface Area: | 17.8 Å2 |
Undefined Atom Stereocenter Count: | 0 |
Undefined Bond Stereocenter Count: | 0 |
XLogP3: | 5.5 |
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