ERRα antagonist-1 - CAS 1072145-33-5

Catalog: BB002001
Product Name: ERRα antagonist-1
CAS: 1072145-33-5
Synonyms: N-(3-(4,5-Dihydrothiazol-2-yl)thiazolidin-2-ylidene)-5H-dibenzo[a,d][7]annulen-5-amine; ERRa antagonist-1; 5H-Dibenzo[a,d]cyclohepten-5-amine, N-[3-(4,5-dihydro-2-thiazolyl)-2-thiazolidinylidene]-
ERRα antagonist-1
Related CAS:1150565-89-1 (Z-isomer)
IUPAC Name:3-(4,5-dihydro-1,3-thiazol-2-yl)-N-(2-tricyclo[9.4.0.03,8]pentadeca-1(15),3,5,7,9,11,13-heptaenyl)-1,3-thiazolidin-2-imine
Description:ERRα antagonist-1, a selective and high affinity antagonist of estrogen-related receptor α (ERRα), inhibits interaction of ERRα with Proliferator-activated Receptor γ Coactivator-1α (PGC-1α) and PGC-1β with IC50s of 170 and 180 nM, respectively. It does not inhibit the interaction of either ERRβ or ERRγ with PGC-1α and PGC-1β coactivator, and also does not inhibit interaction of ERα or ERβ with PGC-1α or SRC-1.
Molecular Weight:377.53
Molecular Formula:C21H19N3S2
Canonical SMILES:C1CSC(=N1)N2CCSC2=NC3C4=CC=CC=C4C=CC5=CC=CC=C35
InChI:InChI=1S/C21H19N3S2/c1-3-7-17-15(5-1)9-10-16-6-2-4-8-18(16)19(17)23-21-24(12-14-26-21)20-22-11-13-25-20/h1-10,19H,11-14H2
InChI Key:OWLQZFQCFCNPKV-UHFFFAOYSA-N
Boiling Point:579.0±60.0°C (Predicted)
Purity:≥95%
Density:1.36±0.1 g/cm3 (Predicted)
Solubility:Soluble in DMSO
Storage:Store at 2-8°C, protect from light
MDL:MFCD17676143
LogP:4.14090

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Related Functional Groups

Oxazole/Thiazole

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