N-(2-Chloro-2-methylpropyl)-N-(3,3-diphenylpropyl)-N-methylamine - CAS 936491-32-6

Catalog:	BB069993
Product Name:	N-(2-Chloro-2-methylpropyl)-N-(3,3-diphenylpropyl)-N-methylamine
CAS:	936491-32-6
Synonyms:	N-(2-Chloro-2-methylpropyl)-N-methyl-γ-phenyl-benzenepropanamine

Technical Data

IUPAC Name:	2-chloro-N-(3,3-diphenylpropyl)-N,2-dimethylpropan-1-amine
Description:	N-(2-Chloro-2-methylpropyl)-N-(3,3-diphenylpropyl)-N-methylamine is a useful synthetic intermediate in the synthesis of Lercanidipine (L179000); a dihydropyridine calcium channel blocker. Antihypertensive.
Molecular Weight:	315.88
Molecular Formula:	C20H26ClN
Canonical SMILES:	CC(C)(CN(C)CCC(C1=CC=CC=C1)C2=CC=CC=C2)Cl
InChI:	InChI=1S/C20H26ClN/c1-20(2,21)16-22(3)15-14-19(17-10-6-4-7-11-17)18-12-8-5-9-13-18/h4-13,19H,14-16H2,1-3H3
InChI Key:	FTCSNVDMFXIZBH-UHFFFAOYSA-N
References:	Bianchi, G., et al. Pharmacol. Res., 21, 193 (1989); Rimoldi, E., et al. Acta Therap., 200, 23 (1994); Argekar, A., et al. J. Pharm. Biomed. Anal., 21, 1137 (2000); Rao, A. S., Novel process for the preparation of lercanidipine and its salts. PCT Int. Appl. WO 2007054969. May 18, 2007.

Complexity:	285
Compound Is Canonicalized:	Yes
Covalently-Bonded Unit Count:	1
Defined Atom Stereocenter Count:	0
Defined Bond Stereocenter Count:	0
Exact Mass:	315.1753775
Formal Charge:	0
Heavy Atom Count:	22
Hydrogen Bond Acceptor Count:	1
Hydrogen Bond Donor Count:	0
Isotope Atom Count:	0
Monoisotopic Mass:	315.1753775
Rotatable Bond Count:	7
Topological Polar Surface Area:	3.2Å²
Undefined Atom Stereocenter Count:	0
Undefined Bond Stereocenter Count:	0
XLogP3:	5.2