MG-132 - CAS 133407-82-6

Catalog	Size	Price	Stock	Quantity
BB007748	100 mg	$239	In stock

Add to cart Inquiry

Technical Data

IUPAC Name:	benzyl N-[(2S)-4-methyl-1-[[(2S)-4-methyl-1-[[(2S)-4-methyl-1-oxopentan-2-yl]amino]-1-oxopentan-2-yl]amino]-1-oxopentan-2-yl]carbamate
Description:	MG-132 is a potent Proteasome inhibitor with potential anticancer activity. MG-132 induces MCPIP1 expression; induces C6 glioma cell apoptosis via oxidative stress; induces AIF nuclear translocation through down-regulation of ERK and Akt/mTOR pathway.
Molecular Weight:	475.62
Molecular Formula:	C26H41N3O5
Canonical SMILES:	CC(C)CC(C=O)NC(=O)C(CC(C)C)NC(=O)C(CC(C)C)NC(=O)OCC1=CC=CC=C1
InChI:	InChI=1S/C26H41N3O5/c1-17(2)12-21(15-30)27-24(31)22(13-18(3)4)28-25(32)23(14-19(5)6)29-26(33)34-16-20-10-8-7-9-11-20/h7-11,15,17-19,21-23H,12-14,16H2,1-6H3,(H,27,31)(H,28,32)(H,29,33)/t21-,22-,23-/m0/s1
InChI Key:	TZYWCYJVHRLUCT-VABKMULXSA-N
Boiling Point:	682 °C at 760 mmHg
Density:	1.073 g/cm³
Solubility:	Soluble in ethanol, chloroform, methanol, water.
Appearance:	White crystalline
MDL:	MFCD00674886
LogP:	4.76090

GHS Hazard Statement:	H315 (100%): Causes skin irritation [Warning Skin corrosion/irritation]; H319 (100%): Causes serious eye irritation [Warning Serious eye damage/eye irritation]; H335 (100%): May cause respiratory irritation [Warning Specific target organ toxicity, single exposure; Respiratory tract irritation]
Precautionary Statement:	P261, P264, P264+P265, P271, P280, P302+P352, P304+P340, P305+P351+P338, P319, P321, P332+P317, P337+P317, P362+P364, P403+P233, P405, and P501
Signal Word:	Warning

Publication Number	Title	Priority Date
CN-112280801-A	Method and kit for rAAV infection titer detection by plasmid assistance	20201030
WO-2021188052-A1	Use of a compound or composition comprising an inhibitor of nlrp1 inflammasome activation for the treatment of human airway inflammation	20200319
WO-2021062202-A1	Methods for depletion of deleterious mitochondrial genomes	20190925
WO-2021035101-A1	Molecules that bind to tdp-43 for the treatment of amyotrophic lateral sclerosis and related disorders	20190822
KR-20210110818-A	RANK antagonists and uses therefor	20181205

PMID	Publication Date	Title	Journal
34717917	20220105	Digitoxin promotes apoptosis and inhibits proliferation and migration by reducing HIF-1α and STAT3 in KRAS mutant human colon cancer cells	Chemico-biological interactions
34416243	20211001	RNF31 mediated ubiquitination of A20 aggravates inflammation and hepatocyte apoptosis through the TLR4/MyD88/NF-κB signaling pathway	Chemico-biological interactions
34516972	20211001	Cadmium induces triglyceride levels via microsomal triglyceride transfer protein (MTTP) accumulation caused by lysosomal deacidification regulated by endoplasmic reticulum (ER) Ca2+ homeostasis	Chemico-biological interactions
33539684	20210601	Curcumin suppresses the stemness of non-small cell lung cancer cells via promoting the nuclear-cytoplasm translocation of TAZ	Environmental toxicology
34021431	20210522	Stimulation of de novo glutathione synthesis by nitrofurantoin for enhanced resilience of hepatocytes	Cell biology and toxicology

Complexity:	644
Compound Is Canonicalized:	Yes
Covalently-Bonded Unit Count:	1
Defined Atom Stereocenter Count:	3
Defined Bond Stereocenter Count:	0
Exact Mass:	475.30462142
Formal Charge:	0
Heavy Atom Count:	34
Hydrogen Bond Acceptor Count:	5
Hydrogen Bond Donor Count:	3
Isotope Atom Count:	0
Monoisotopic Mass:	475.30462142
Rotatable Bond Count:	15
Topological Polar Surface Area:	114
Undefined Atom Stereocenter Count:	0
Undefined Bond Stereocenter Count:	0
XLogP3:	4.8