Methyl malonyl chloride - CAS 37517-81-0

Name: Methyl malonyl chloride
Brand: BOC Sciences
Rating: 5 (1 reviews)

Catalog:	BB023316
Product Name:	Methyl malonyl chloride
CAS:	37517-81-0
Synonyms:	methyl 3-chloro-3-oxopropanoate

Technical Data

Safety and Hazards

Patents

Literatures

Computed Properties

IUPAC Name:	methyl 3-chloro-3-oxopropanoate
Description:	Methyl malonyl chloride (CAS# 37517-81-0) is a reagent that is used in the synthesis of pyrrolopiperidinone acetic acids as CRTh2 antagonists.
Molecular Weight:	136.53
Molecular Formula:	C4H5ClO3
Canonical SMILES:	COC(=O)CC(=O)Cl
InChI:	InChI=1S/C4H5ClO3/c1-8-4(7)2-3(5)6/h2H2,1H3
InChI Key:	UTBCRHAMJFMIIR-UHFFFAOYSA-N
Boiling Point:	57-59 °C (12 mmHg)
Density:	1.273 g/cm³
MDL:	MFCD00013657
LogP:	0.31490

Related Products

Online Inquiry

Name:

* Phone:

* Service & Products of Interested:

Project Description:

* Quantity:

* Email:

* Verification Code:

Customer Support

If the product you need is not in our catalog, please contact us in time to submit your needs. You can help our website get better and better. Why not submit the request today?

Submit Requirement

Customer Centered

Global Delivery

Warehouses in multiple cities to ensure fast delivery

Quality Assurance

Strict process parameter control to ensure product quality

Large Stock

> 20,000 building blocks and intermediates from stock

Process Scale-up

Process scale-up from lab to industrial scale

Flexible Batch Size

Flexible batch size for diverse industrial demands

Related Functional Groups

Carbonyl Compounds

[89908-23-6]C23H22N2O5
2-Propenoic acid, 2-(3',3'-dimethyl-6-nitrospiro[2H-1-benzopyran-2,2'-[2H]indol]-1'(3'H)-yl)ethyl ester
[87-88-7]C6H2Cl2O4
Chloranilic acid
[1383427-98-2]C7H13ClN2O2
(S)-Hexahydropyrazino[2,1-c][1,4]oxazin-4(3H)-one hydrochloride
[17746-05-3]C11H21ClO
Undecanoyl chloride
[959574-98-2]C11H10N2O2
(3-Phenyl-1H-pyrazol-1-yl)acetic acid
[1006443-01-1]C9H6N4O4
1-(5-Nitropyridin-2-yl)-1H-pyrazole-3-carboxylic acid

GHS Hazard Statement:	H314 (100%): Causes severe skin burns and eye damage [Danger Skin corrosion/irritation]
Precautionary Statement:	P260, P261, P264, P271, P280, P301+P330+P331, P303+P361+P353, P304+P340, P305+P351+P338, P310, P312, P321, P363, P403+P233, P405, and P501
Signal Word:	Danger

Publication Number	Title	Priority Date
CN-111471045-A	Preparation method of tofacitinib impurity	20200421
CN-112920186-A	Preparation method of tofacitinib impurity	20200421
WO-2021203025-A1	1 h-pyrazolo[4,3-g]isoquinoline and 1 h-pyrazolo[4,3-g]quinoline derivatives as alpha-1 -antitrypsin modulators for treating alpha-1 -antitrypsin deficiency (aatd)	20200403
WO-2021174355-A1	Inhibitors of human herpesviruses	20200303
WO-2021173591-A1	Compounds and methods of use	20200224

PMID	Publication Date	Title	Journal
22509205	20120101	Synthesis and mesomorphic properties of calamitic malonates and cyanoacetates tethered to 4-cyanobiphenyls	Beilstein journal of organic chemistry
18698465	20080907	Synthesis and solution structure of 3,5-dioxopimelic acid diesters--stable 1,3,5,7-tetracarbonyl derivatives	Organic & biomolecular chemistry
11374991	20010601	A new route to 7-substituted derivatives of n-[4-(2-[2-amino-3,4-dihydro-4-oxo-7H-pyrrolo(2,3-d)pyrimidin-5-yl]ethyl)benzoyl]-L-glutamic acid [ALIMTA (LY231514, MTA)]	The Journal of organic chemistry

Complexity:	110
Compound Is Canonicalized:	Yes
Covalently-Bonded Unit Count:	1
Defined Atom Stereocenter Count:	0
Defined Bond Stereocenter Count:	0
Exact Mass:	135.9927217
Formal Charge:	0
Heavy Atom Count:	8
Hydrogen Bond Acceptor Count:	3
Hydrogen Bond Donor Count:	0
Isotope Atom Count:	0
Monoisotopic Mass:	135.9927217
Rotatable Bond Count:	3
Topological Polar Surface Area:	43.4 Å²
Undefined Atom Stereocenter Count:	0
Undefined Bond Stereocenter Count:	0
XLogP3:	0.6