Methyl dichlorophosphate - CAS 677-24-7

Catalog:	BB033376
Product Name:	Methyl dichlorophosphate
CAS:	677-24-7
Synonyms:	dichlorophosphoryloxymethane

Technical Data

Safety and Hazards

Patents

Literatures

Computed Properties

IUPAC Name:	dichlorophosphoryloxymethane
Description:	Methyl dichlorophosphate (CAS# 677-24-7) is useful for the synthesis of novel polycyclic phosphates. Also, it is used to synthesize potent C-10 carba artemisinin dimers against P. falciparum malaria parasites and HL-60 cancer cells.
Molecular Weight:	148.91
Molecular Formula:	CH3Cl2O2P
Canonical SMILES:	COP(=O)(Cl)Cl
InChI:	InChI=1S/CH3Cl2O2P/c1-5-6(2,3)4/h1H3
InChI Key:	SNVCRNWSNUUGEA-UHFFFAOYSA-N
Boiling Point:	62-64 °C15 mmHg (lit.)
Purity:	> 95.0 % (T)
Density:	1.488 g/cm³
Appearance:	Colorless to light yellow clear liquid
LogP:	2.21850

Publication Number	Title	Priority Date
CN-113336794-A	Novel saccharide bio-based cyclic phosphorus/phosphonate and preparation method and application thereof	20210531
CN-112851909-A	Storage-stable polyisocyanate composition	20210114
CN-112680972-A	Flame-retardant polyester fabric and preparation method thereof	20210111
CN-112480565-A	Phosphorus-containing cardanol-based flame-retardant plasticizer for modified polyvinyl chloride and preparation method and application thereof	20201127
CN-112661788-A	Phosphorus-containing polyaspartic acid ester and preparation method and application thereof	20201117

PMID	Publication Date	Title	Journal
16557311	20060407	Synthesis of oligosaccharides corresponding to Vibrio cholerae O139 polysaccharide structures containing dideoxy sugars and a cyclic phosphate	Organic & biomolecular chemistry
15027860	20040325	Enzymatic release of antitumor ether lipids by specific phospholipase A2 activation of liposome-forming prodrugs	Journal of medicinal chemistry

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Related Functional Groups

Phosphorus Compounds

[52378-69-5]
Diethyl trans-cinnamylphosphonate
[4671-77-6]
1,4-Butanediphosphonic acid
[84962-98-1]
3-(Trihydroxysilyl)propyl methylphosphonate, monosodium salt solution
[115826-95-4]
Dichloro[(R)-(+)-2,2'-bis(diphenylphosphino)-1,1'-binaphthyl]palladium(II)
[55552-24-4]
Ethyl (diphenylphosphino)acetate
[35051-50-4]
Ethyl 2-(diethoxyphosphoryl)-3-methylbutanoate

GHS Hazard Statement:	H314 (100%): Causes severe skin burns and eye damage [Danger Skin corrosion/irritation]
Precautionary Statement:	P260, P264, P280, P301+P330+P331, P303+P361+P353, P304+P340, P305+P351+P338, P310, P321, P363, P405, and P501
Signal Word:	Danger

Complexity:	75.6
Compound Is Canonicalized:	Yes
Covalently-Bonded Unit Count:	1
Defined Atom Stereocenter Count:	0
Defined Bond Stereocenter Count:	0
Exact Mass:	147.9247717
Formal Charge:	0
Heavy Atom Count:	6
Hydrogen Bond Acceptor Count:	2
Hydrogen Bond Donor Count:	0
Isotope Atom Count:	0
Monoisotopic Mass:	147.9247717
Rotatable Bond Count:	1
Topological Polar Surface Area:	26.3 Å²
Undefined Atom Stereocenter Count:	0
Undefined Bond Stereocenter Count:	0
XLogP3:	1