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| Description: | Methyl 4-[(3-chloro-2-fluorophenyl)methyl]-1-piperazinecarboxylate is an intermediate in the synthesis of CK 1827452 (C544000), a promising new drug in systolic heart failure. It accelerates the transition of myosin into the force-generating state without affecting cardiac myocyte calcium homeostasis. CK 1827452 increases cardiac function by increasing the duration of ejection without changing the rates of contraction. |
| Molecular Weight: | 286.73 |
| Molecular Formula: | C13H16ClFN2O2 |
| References: | Meijs, M. et al. Eur. J. Heart. Fail., 14, 232 (2012); Malik, F. et al. J. Mol. Cell. Card., 51, 454 (2011). |
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