Methyl 2-Benzyl-5-hydroxy-2H-pyrazole-3-carboxylate - CAS 52867-49-9

Catalog: BB076359
Product Name: Methyl 2-Benzyl-5-hydroxy-2H-pyrazole-3-carboxylate
CAS: 52867-49-9
Synonyms: 1-Benzyl-3-hydroxy-5-methoxycarbonyl-1H-pyrazole;Methyl 2-benzyl-5-oxo-2,5-dihydro-1H-pyrazole-3-carboxylate
Methyl 2-Benzyl-5-hydroxy-2H-pyrazole-3-carboxylate
IUPAC Name:methyl 2-benzyl-5-oxo-1H-pyrazole-3-carboxylate
Description:Methyl 2-benzyl-5-hydroxy-2H-pyrazole-3-carboxylate is an intermediate for the synthesis of CFM 1571 Hydrochloride (C291720), which acts as a soluble guanylyl cyclase (sGC) activator while ignoring adenylyl cyclase. Inhibits collagen-stimulated platelet aggregation in vitro.
Molecular Weight:232.24
Molecular Formula:C12H12N2O3
Canonical SMILES:COC(=O)C1=CC(=O)NN1CC2=CC=CC=C2
InChI:InChI=1S/C12H12N2O3/c1-17-12(16)10-7-11(15)13-14(10)8-9-5-3-2-4-6-9/h2-7H,8H2,1H3,(H,13,15)
InChI Key:UFYYVUADSYAISN-UHFFFAOYSA-N
Solubility:Ethyl Acetate; Chloroform; DMSO; Methanol
Appearance:White Solid
References:Kotzki, S. et al. J. Pharm. Exp. Ther., 346, 424 (2013); Selwood, D> et al. J. Med. CHem., 44, 78 (2001).

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