m-PEG8-COOH - CAS 1093647-41-6
Catalog: |
BB002444 |
Product Name: |
m-PEG8-COOH |
CAS: |
1093647-41-6 |
Synonyms: |
mPEG7-propionic acid; m-PEG8-acid; 4,7,10,13,16,19,22,25-Octaoxahexacosanoic acid; mPEG7-CH2CH2COOH; 2,5,8,11,14,17,20,23-Octaoxahexacosan-26-oic acid; MPEG7-OCH2CH2COOH |
IUPAC Name: | 3-[2-[2-[2-[2-[2-[2-(2-methoxyethoxy)ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]propanoic acid |
Description: | m-PEG8-COOH is a non-cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). |
Molecular Weight: | 412.47 |
Molecular Formula: | C18H36O10 |
Canonical SMILES: | COCCOCCOCCOCCOCCOCCOCCOCCC(=O)O |
InChI: | InChI=1S/C18H36O10/c1-21-4-5-23-8-9-25-12-13-27-16-17-28-15-14-26-11-10-24-7-6-22-3-2-18(19)20/h2-17H2,1H3,(H,19,20) |
InChI Key: | JHUSQXBQANBSDC-UHFFFAOYSA-N |
Boiling Point: | 503.0±50.0 °C at 760 mmHg |
Flash Point: | 164.2±23.6 °C |
Purity: | ≥95% |
Density: | 1.111±0.06 g/cm3 (Predicted) |
Solubility: | Soluble in DCM, DMF, DMSO, Water |
Appearance: | Pale Yellow Oily Liquid |
Storage: | Store at 2-8°C |
LogP: | -2.78 |
Vapor Pressure: | 0.0±2.8 mmHg at 25°C |
Publication Number | Title | Priority Date |
US-2019365915-A1 | Modified self-immolating moieties for use in prodrugs and conjugates and methods of using and making | 20180529 |
WO-2019231879-A1 | Modified self-immolating moieties for use in prodrugs and conjugates and methods of using and making | 20180529 |
AU-2019277094-A1 | Modified self-immolating moieties for use in prodrugs and conjugates and methods of using and making | 20180529 |
BR-112020024022-A2 | modified self-adhesive portions for use in prodrugs and conjugates and methods of use and preparation | 20180529 |
EP-3801629-A1 | Modified self-immolating moieties for use in prodrugs and conjugates and methods of using and making | 20180529 |
Complexity: | 317 |
Compound Is Canonicalized: | Yes |
Covalently-Bonded Unit Count: | 1 |
Defined Atom Stereocenter Count: | 0 |
Defined Bond Stereocenter Count: | 0 |
Exact Mass: | 412.23084734 |
Formal Charge: | 0 |
Heavy Atom Count: | 28 |
Hydrogen Bond Acceptor Count: | 10 |
Hydrogen Bond Donor Count: | 1 |
Isotope Atom Count: | 0 |
Monoisotopic Mass: | 412.23084734 |
Rotatable Bond Count: | 24 |
Topological Polar Surface Area: | 111 |
Undefined Atom Stereocenter Count: | 0 |
Undefined Bond Stereocenter Count: | 0 |
XLogP3: | -1.5 |
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