Loratadine EP Impurity H - CAS 29976-53-2
Catalog: |
BB020400 |
Product Name: |
Loratadine EP Impurity H |
CAS: |
29976-53-2 |
Synonyms: |
N-Carbethoxy-4-piperidone; 1-(Carboethoxy)-4-piperidinone; 1-(Carboethoxy)-4-piperidone; 1-(Ethoxycarbonyl)-4-piperidone; 1-Carbethoxy-4-piperidone; 1-Carbethoxypiperidin-4-one; 1-Ethoxycarbonyl-4-oxopiperidine; 1-Ethoxycarbonyl-4-piperidinone; 4-Oxo-1-piperidinecarboxylic Acid Ethyl Ester; Ethyl 4-Oxo-1-piperidinecarboxylate; N-(Ethoxycarbonyl)-4-piperidone; N-Carbethoxy-4-piperidinone; N-Ethoxycarbonyl-4-piperidinone; NSC 139022; 1-Piperidinecarboxylic acid, 4-oxo-, ethyl ester |
IUPAC Name: | ethyl 4-oxopiperidine-1-carboxylate |
Description: | Loratadine EP Impurity H is an impurity of Loratadine, which is a histamine H1 receptor antagonist used to treat allergies. |
Molecular Weight: | 171.19 |
Molecular Formula: | C8H13NO3 |
Canonical SMILES: | CCOC(=O)N1CCC(=O)CC1 |
InChI: | InChI=1S/C8H13NO3/c1-2-12-8(11)9-5-3-7(10)4-6-9/h2-6H2,1H3 |
InChI Key: | LUBGFMZTGFXIIN-UHFFFAOYSA-N |
Boiling Point: | 93-94°C at 1 Torr |
Purity: | ≥95% |
Density: | 1.155±0.06 g/cm3 |
Solubility: | Soluble in Chloroform (Slightly), Methanol (Slightly) |
Appearance: | Clear Light Yellow Oily Matter |
Storage: | Store at 2-8°C |
MDL: | MFCD00006188 |
LogP: | 0.74570 |
GHS Hazard Statement: | H302 (71.43%): Harmful if swallowed [Warning Acute toxicity, oral] |
Precautionary Statement: | P261, P264, P270, P271, P280, P301+P312, P302+P352, P304+P340, P305+P351+P338, P312, P321, P330, P332+P313, P337+P313, P362, P403+P233, P405, and P501 |
Signal Word: | Warning |
Publication Number | Title | Priority Date |
CN-112341433-A | Preparation method of loratadine | 20201116 |
CN-112062767-A | Preparation method and intermediate of rumepilone | 20201020 |
CN-111423454-A | Piperazine compound and application thereof in preparing chemokine receptor CCR2 antagonist | 20200424 |
CN-111423454-B | Piperazine compound and application thereof in preparing chemokine receptor CCR2 antagonist | 20200424 |
CZ-202094-A3 | Solid salt forms of elafibranor | 20200224 |
PMID | Publication Date | Title | Journal |
21773066 | 20110401 | A new validated liquid chromatographic method for the determination of loratadine and its impurities | Scientia pharmaceutica |
Complexity: | 181 |
Compound Is Canonicalized: | Yes |
Covalently-Bonded Unit Count: | 1 |
Defined Atom Stereocenter Count: | 0 |
Defined Bond Stereocenter Count: | 0 |
Exact Mass: | 171.08954328 |
Formal Charge: | 0 |
Heavy Atom Count: | 12 |
Hydrogen Bond Acceptor Count: | 3 |
Hydrogen Bond Donor Count: | 0 |
Isotope Atom Count: | 0 |
Monoisotopic Mass: | 171.08954328 |
Rotatable Bond Count: | 2 |
Topological Polar Surface Area: | 46.6 Å2 |
Undefined Atom Stereocenter Count: | 0 |
Undefined Bond Stereocenter Count: | 0 |
XLogP3: | -0.1 |
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