Isopropyl myristate - CAS 110-27-0

Technical Data

IUPAC Name:	propan-2-yl tetradecanoate
Description:	Isopropyl myristate is an emollient ester of low viscosity for topical delivery of pharmaceuticals.
Molecular Weight:	270.45
Molecular Formula:	C17H34O2
Canonical SMILES:	CCCCCCCCCCCCCC(=O)OC(C)C
InChI:	InChI=1S/C17H34O2/c1-4-5-6-7-8-9-10-11-12-13-14-15-17(18)19-16(2)3/h16H,4-15H2,1-3H3
InChI Key:	AXISYYRBXTVTFY-UHFFFAOYSA-N
Boiling Point:	167 °C at 9 mmHg
Melting Point:	-5°C
Flash Point:	29.6 dyne/cm Density: 0.864 g/cm³
Purity:	98%+
Density:	0.853 g/cm³
Solubility:	Soluble in chloroform (slightly), ethyl acetate (slightly).
Appearance:	Clear colorless oil
Storage:	Room Temperature
Decomposition:	When heated to decomposition it emits toxic smoke and fumes
MDL:	MFCD00008982
LogP:	5.63910
Refractive Index:	1.434-1.436
Stability:	Stable. Combustible. Incompatible with strong oxidizing agents.
Vapor Pressure:	0.000329mmHg at 25°C

GHS Hazard Statement:	H315 (99.79%): Causes skin irritation [Warning Skin corrosion/irritation]
Precautionary Statement:	P264, P280, P302+P352, P321, P332+P313, and P362
Signal Word:	Warning

Publication Number	Title	Priority Date
US-11033516-B1	Combination therapies with disulfiram	20200918
US-10836729-B1	Metabolically stable 5-HMF derivatives for the treatment of hypoxia	20200504
US-10836757-B1	Polymorphic forms of metopimazine	20200402
US-11007134-B1	Ceramide containing capsules, ceramide compositions, and cosmetic compositions thereof	20200331
US-10780139-B1	Hypericum revolutum extract as a vasodilator	20200319

PMID	Publication Date	Title	Journal
28132900	20170501	Influence of the penetration enhancer isopropyl myristate on stratum corneum lipid model membranes revealed by neutron diffraction and 2H NMR experiments	Biochimica et biophysica acta. Biomembranes
22324326	20121201	The influence of the structure and the composition of water/AOT-Tween 85/IPM microemulsion system on transdermal delivery of 5-fluorouracil	Drug development and industrial pharmacy
22348223	20121201	Artesunate-loaded chitosan/lecithin nanoparticles: preparation, characterization, and in vivo studies	Drug development and industrial pharmacy
22928552	20121201	The role of vehicle interactions on permeation of an active through model membranes and human skin	International journal of cosmetic science
22972714	20121201	Formulation and in vitro/in vivo correlation of a drug-in-adhesive transdermal patch containing azasetron	Journal of pharmaceutical sciences

Complexity:	199
Compound Is Canonicalized:	Yes
Covalently-Bonded Unit Count:	1
Defined Atom Stereocenter Count:	0
Defined Bond Stereocenter Count:	0
Exact Mass:	270.255880323
Formal Charge:	0
Heavy Atom Count:	19
Hydrogen Bond Acceptor Count:	2
Hydrogen Bond Donor Count:	0
Isotope Atom Count:	0
Monoisotopic Mass:	270.255880323
Rotatable Bond Count:	14
Topological Polar Surface Area:	26.3 Å²
Undefined Atom Stereocenter Count:	0
Undefined Bond Stereocenter Count:	0
XLogP3:	7.2