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| IUPAC Name: | 1H-indole-5-carboxamide |
| Description: | SD-169 is an ATP-competitive and orally bioactive inhibitor of p38α MAP kinase (IC50 = 3.2 nM) with 38 fold selectivity over p38β MAP kinase (IC50 = 122 nM). SD-169 decreases p38 MAP kinase expression in T cells, lowers blood glucose and reduces the risk of diabetes. It has no inhibitory effect against a panel of other kinases including p38γ MAP kinase, ERK2, JNK-1 and MAPKAPK-2. |
| Molecular Weight: | 160.17 |
| Molecular Formula: | C9H8N2O |
| Canonical SMILES: | C1=CC2=C(C=CN2)C=C1C(=O)N |
| InChI: | InChI=1S/C9H8N2O/c10-9(12)7-1-2-8-6(5-7)3-4-11-8/h1-5,11H,(H2,10,12) |
| InChI Key: | GQMYQEAXTITUAE-UHFFFAOYSA-N |
| Boiling Point: | 457.6±18.0 °C (Predicted) |
| Melting Point: | 162-164 °C |
| Purity: | 99 % |
| Density: | 1.328±0.06 g/cm3 (Predicted) |
| Solubility: | Soluble in DMSO (Slightly), Methanol (Slightly) |
| Appearance: | Off-white to light purple solid |
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Flexible batch size for diverse industrial demandsRelated Functional Groups
Amines and Anilines
[(2,3-Difluorophenyl)methyl][(1,3-dimethylpyrazol-4-yl)methyl]amine
2,2-Difluoro-N-(2-morpholin-4-ylethyl)ethanamine dihydrochloride
Carbonyl Compounds
(S)-Hexahydropyrazino[2,1-c][1,4]oxazin-4(3H)-one hydrochloride
Indoles
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