Indole-5-carboxamide - CAS 1670-87-7

Catalog: BB046666
Product Name: Indole-5-carboxamide
CAS: 1670-87-7
Synonyms: SD-169; SD169; 5-(Aminocarbonyl)-1H-indole; 5-Carbamoylindole
Indole-5-carboxamide
IUPAC Name:1H-indole-5-carboxamide
Description:SD-169 is an ATP-competitive and orally bioactive inhibitor of p38α MAP kinase (IC50 = 3.2 nM) with 38 fold selectivity over p38β MAP kinase (IC50 = 122 nM). SD-169 decreases p38 MAP kinase expression in T cells, lowers blood glucose and reduces the risk of diabetes. It has no inhibitory effect against a panel of other kinases including p38γ MAP kinase, ERK2, JNK-1 and MAPKAPK-2.
Molecular Weight:160.17
Molecular Formula:C9H8N2O
Canonical SMILES:C1=CC2=C(C=CN2)C=C1C(=O)N
InChI:InChI=1S/C9H8N2O/c10-9(12)7-1-2-8-6(5-7)3-4-11-8/h1-5,11H,(H2,10,12)
InChI Key:GQMYQEAXTITUAE-UHFFFAOYSA-N
Boiling Point:457.6±18.0 °C (Predicted)
Melting Point:162-164 °C
Purity:99 %
Density:1.328±0.06 g/cm3 (Predicted)
Solubility:Soluble in DMSO (Slightly), Methanol (Slightly)
Appearance:Off-white to light purple solid

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Related Functional Groups

Amines and Anilines

Carbonyl Compounds

Indoles

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