Hydroxy-PEG2-t-butyl ester - CAS 133803-81-3
Catalog: |
BB007815 |
Product Name: |
Hydroxy-PEG2-t-butyl ester |
CAS: |
133803-81-3 |
Synonyms: |
HO-PEG2-CH2CH2COOtBu; Hydroxy-PEG2-(CH2)2-Boc; OH-PEG2-TBA; OH-PEG2-CH2CH2COOtBu; HO-PEG2-t-butyl ester; Propanoic acid, 3-[2-(2-hydroxyethoxy)ethoxy]-, 1,1-dimethylethyl ester; t-Butyl 9-hydroxy-4,7-dioxanonanoate; 3-[2-(2-hydroxyethoxy)ethoxy]propionic acid t-butyl ester; 2-Methyl-2-propanyl 3-[2-(2-hydroxyethoxy)ethoxy]propanoate |
Related CAS: | 1186025-29-5 (polymer) 892154-71-1 (polymer)
|
IUPAC Name: | tert-butyl 3-[2-(2-hydroxyethoxy)ethoxy]propanoate |
Description: | Hydroxy-PEG2-(CH2)2-Boc is a uncleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). Hydroxy-PEG2-(CH2)2-Boc is extracted from patent WO2004008101A2 (compound 196). |
Molecular Weight: | 234.29 |
Molecular Formula: | C11H22O5 |
Canonical SMILES: | CC(C)(C)OC(=O)CCOCCOCCO |
InChI: | InChI=1S/C11H22O5/c1-11(2,3)16-10(13)4-6-14-8-9-15-7-5-12/h12H,4-9H2,1-3H3 |
InChI Key: | OKOWESVURLUVMD-UHFFFAOYSA-N |
Boiling Point: | 321.8±22.0 °C at 760 mmHg |
Purity: | ≥95% |
Density: | 1.046±0.1 g/cm3 |
Solubility: | Soluble in DMSO (10 mm) |
Appearance: | Pale Yellow or Colorless Oily Liquid |
Storage: | Store at 2-8°C |
LogP: | 0.74370 |
Publication Number | Title | Priority Date |
JP-2021073185-A | Its use in novel conjugates and specific conjugation of biomolecules with drugs | 20201224 |
WO-2021207691-A1 | Phthalocyanine dye compounds, conjugates and methods of use thereof | 20200410 |
WO-2021127460-A1 | Pcsk9 antagonist compounds | 20191220 |
WO-2021066873-A1 | Condensed heterocycles as bcl-2 inhibitors | 20191003 |
US-2020276176-A1 | Compounds for targeting mutant huntingtin protein and uses thereof | 20190225 |
Complexity: | 185 |
Compound Is Canonicalized: | Yes |
Covalently-Bonded Unit Count: | 1 |
Defined Atom Stereocenter Count: | 0 |
Defined Bond Stereocenter Count: | 0 |
Exact Mass: | 234.1467238 |
Formal Charge: | 0 |
Heavy Atom Count: | 16 |
Hydrogen Bond Acceptor Count: | 5 |
Hydrogen Bond Donor Count: | 1 |
Isotope Atom Count: | 0 |
Monoisotopic Mass: | 234.1467238 |
Rotatable Bond Count: | 10 |
Topological Polar Surface Area: | 65 |
Undefined Atom Stereocenter Count: | 0 |
Undefined Bond Stereocenter Count: | 0 |
XLogP3: | 0.1 |
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