HO-PEG1-CH2-COOH - CAS 13382-47-3
Catalog: |
BB007822 |
Product Name: |
HO-PEG1-CH2-COOH |
CAS: |
13382-47-3 |
Synonyms: |
beta-Hydroxyethoxyacetic acid; Acetic acid, (2-hydroxyethoxy)-; Acetic acid, 2-(2-hydroxyethoxy)-; Hydroxy-PEG1-CH2CO2H; Hydroxy-PEG1-acetic acid |
Related CAS: | 142047-97-0 (sodium salt) 916430-91-6 (polymer)
|
IUPAC Name: | 2-(2-hydroxyethoxy)acetic acid |
Description: | HO-PEG1-CH2-COOH is a polyethylene glycol (PEG)-based PROTAC linker that can be used in the synthesis of a series of PROTACs. |
Molecular Weight: | 120.10 |
Molecular Formula: | C4H8O4 |
Canonical SMILES: | C(COCC(=O)O)O |
InChI: | InChI=1S/C4H8O4/c5-1-2-8-3-4(6)7/h5H,1-3H2,(H,6,7) |
InChI Key: | VDNMIIDPBBCMTM-UHFFFAOYSA-N |
Boiling Point: | 323.8±17.0°C at 760 mmHg |
Melting Point: | 44°C |
Purity: | ≥95% |
Density: | 1.290±0.1 g/cm3 |
Solubility: | Soluble in DMSO |
Storage: | Store at 2-8°C |
LogP: | -0.92010 |
Publication Number | Title | Priority Date |
US-2012070650-A1 | Biomedical implants comprising surface-modified metal particles and biodegradable polymers, its use for suppressing inflammation, and preparation method thereof | 20100916 |
EP-2558577-A1 | Bi-functional complexes and methods for making and using such complexes | 20100416 |
US-2013281324-A1 | Bi-functinal complexes and methods for making and using such complexes | 20100416 |
WO-2011127933-A1 | Bi-functional complexes and methods for making and using such complexes | 20100416 |
EP-2504327-A1 | Orthoester derivatives of crown ethers as carriers for pharmaceutical and diagnostic compositions | 20091125 |
PMID | Publication Date | Title | Journal |
23827505 | 20130829 | Diglycolic acid inhibits succinate dehydrogenase activity in human proximal tubule cells leading to mitochondrial dysfunction and cell death | Toxicology letters |
22694101 | 20120701 | Management of diethylene glycol ingestion | Clinical toxicology (Philadelphia, Pa.) |
22458541 | 20120521 | Lactone metabolite common to the carcinogens dioxane, diethylene glycol, and N-nitrosomorpholine: aqueous chemistry and failure to mediate liver carcinogenesis in the F344 rat | Chemical research in toxicology |
22152129 | 20111212 | Synthesis and properties of acetamidinium salts | Chemistry Central journal |
21856646 | 20111101 | Diglycolic acid is the nephrotoxic metabolite in diethylene glycol poisoning inducing necrosis in human proximal tubule cells in vitro | Toxicological sciences : an official journal of the Society of Toxicology |
Complexity: | 70.4 |
Compound Is Canonicalized: | Yes |
Covalently-Bonded Unit Count: | 1 |
Defined Atom Stereocenter Count: | 0 |
Defined Bond Stereocenter Count: | 0 |
Exact Mass: | 120.04225873 |
Formal Charge: | 0 |
Heavy Atom Count: | 8 |
Hydrogen Bond Acceptor Count: | 4 |
Hydrogen Bond Donor Count: | 2 |
Isotope Atom Count: | 0 |
Monoisotopic Mass: | 120.04225873 |
Rotatable Bond Count: | 4 |
Topological Polar Surface Area: | 66.8 |
Undefined Atom Stereocenter Count: | 0 |
Undefined Bond Stereocenter Count: | 0 |
XLogP3: | -1 |
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