Foscarnet Sodium Hexahydrate - CAS 34156-56-4
Catalog: |
BB021984 |
Product Name: |
Foscarnet Sodium Hexahydrate |
CAS: |
34156-56-4 |
Synonyms: |
Sodium phosphonoformate tribasic hexahydrate; 1,1-Dihydroxyphosphinecarboxylic Acid 1-Oxide Sodium Salt Hydrate; A 29622 Hydrate; EHB 776 Hydrate; Foscavir Hydrate; Gefin Hydrate; PFA Hydrate; Phosphonoformic Acid Trisodium Salt Hydrate; Triapten Hexahydrate; Trisodium Phosphonoformate Hexahydrate |
Related CAS: | 4428-95-9 (anhydrous free acid) 63585-09-1 (anhydrous)
|
IUPAC Name: | trisodium;phosphonatoformate;hexahydrate |
Description: | Foscarnet Sodium Hexahydrate is an antiviral drug used in the treatment of cytomegalovirus retinitis. It has inhibitory effect on viral DNA polymerase and reverse transcriptase. |
Molecular Weight: | 300.04 |
Molecular Formula: | CH12Na3O11P |
Canonical SMILES: | C(=O)([O-])P(=O)([O-])[O-].O.O.O.O.O.O.[Na+].[Na+].[Na+] |
InChI: | InChI=1S/CH3O5P.3Na.6H2O/c2-1(3)7(4,5)6;;;;;;;;;/h(H,2,3)(H2,4,5,6);;;;6*1H2/q;3*+1;;;;;;/p-3 |
InChI Key: | ILRVASBWNRYBFD-UHFFFAOYSA-K |
Boiling Point: | 490.7 °C |
Melting Point: | >300°C |
Purity: | 95% |
Solubility: | Soluble in Water (Sparingly, Heated) |
Appearance: | White to Off-white Solid |
Storage: | Store at 2-8°C |
MDL: | MFCD00150176 |
LogP: | -1.00200 |
GHS Hazard Statement: | H315 (91.3%): Causes skin irritation [Warning Skin corrosion/irritation] |
Precautionary Statement: | P261, P264, P271, P280, P302+P352, P304+P340, P305+P351+P338, P312, P321, P332+P313, P337+P313, P362, P403+P233, P405, and P501 |
Signal Word: | Warning |
Publication Number | Title | Priority Date |
WO-2020138402-A1 | Antiviral agent for treating or preventing alzheimer's disease and use thereof | 20181227 |
CN-105294567-A | Substituted 3-fluorophenyl methanol compound, pharmaceutical composition and application | 20151029 |
CN-104876849-A | Indole derivative and applications thereof | 20150115 |
CN-105017139-A | Preparation and application of 3,4-disubstituted-6-phenethyl pyridinone HIV-1 reverse transcriptase inhibitor | 20140418 |
AU-2014349256-A1 | Sprayable topical carrier and composition comprising phosphatidylcholine | 20131114 |
PMID | Publication Date | Title | Journal |
23598281 | 20130614 | Formation of a quaternary complex of HIV-1 reverse transcriptase with a nucleotide-competing inhibitor and its ATP enhancer | The Journal of biological chemistry |
22766024 | 20120901 | Crystal precipitation and granulomatous inflammation in multiple organs after foscarnet therapy in a lung transplant recipient | The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation |
22576078 | 20120801 | Human Herpesvirus-6 cytopathic inclusions: an exceptional and recognizable finding on skin biopsy during HHV6 reactivation after autologous stem-cell transplantation | The American Journal of dermatopathology |
22931666 | 20120801 | [Clinical analysis of cytomegalovirus infection after allogeneic hematopoietic stem cell transplantation] | Zhongguo shi yan xue ye xue za zhi |
22398036 | 20120601 | Emergence of cytomegalovirus resistance to foscarnet in a patient receiving foscarnet salvage therapy for multidrug-resistant HIV infection | Journal of clinical virology : the official publication of the Pan American Society for Clinical Virology |
Complexity: | 103 |
Compound Is Canonicalized: | Yes |
Covalently-Bonded Unit Count: | 10 |
Defined Atom Stereocenter Count: | 0 |
Defined Bond Stereocenter Count: | 0 |
Exact Mass: | 299.98103104 |
Formal Charge: | 0 |
Heavy Atom Count: | 16 |
Hydrogen Bond Acceptor Count: | 11 |
Hydrogen Bond Donor Count: | 6 |
Isotope Atom Count: | 0 |
Monoisotopic Mass: | 299.98103104 |
Rotatable Bond Count: | 0 |
Topological Polar Surface Area: | 109 Å2 |
Undefined Atom Stereocenter Count: | 0 |
Undefined Bond Stereocenter Count: | 0 |
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