Fmoc-N-amido-PEG8-propionic acid - CAS 756526-02-0

Name: Fmoc-N-amido-PEG8-propionic acid
Brand: BOC Sciences
Rating: 5 (1 reviews)

Catalog:	BB035366
Product Name:	Fmoc-N-amido-PEG8-propionic acid
CAS:	756526-02-0
Synonyms:	Fmoc-N-amido-PEG8-acid; 1-(9H-Fluoren-9-yl)-3-oxo-2,7,10,13,16,19,22,25,28-nonaoxa-4-azahentriacontan-31-oic acid; Fmoc-NH-PEG8-CH2CH2COOH; 1-(Fmoc-amino)-3,6,9,12,15,18,21,24-octaoxaheptacosan-27-oic Acid; Fmoc-PEG8-propionic acid; 5,8,11,14,17,20,23,26-Octaoxa-2-azanonacosanedioic acid, 1-(9-fluren-9-ylmethyl)ester; 2,7,10,13,16,19,22,25,28-Nonaoxa-4-azahentriacontan-31-oic acid, 1-(9H-fluoren-9-yl)-3-oxo-

Technical Data

Related CAS:	850312-72-0 (polymer)
IUPAC Name:	3-[2-[2-[2-[2-[2-[2-[2-[2-(9H-fluoren-9-ylmethoxycarbonylamino)ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]propanoic acid
Description:	Fmoc-NH-PEG8-CH2CH2COOH is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs).
Molecular Weight:	663.75
Molecular Formula:	C34H49NO12
Canonical SMILES:	C1=CC=C2C(=C1)C(C3=CC=CC=C32)COC(=O)NCCOCCOCCOCCOCCOCCOCCOCCOCCC(=O)O
InChI:	InChI=1S/C34H49NO12/c36-33(37)9-11-39-13-15-41-17-19-43-21-23-45-25-26-46-24-22-44-20-18-42-16-14-40-12-10-35-34(38)47-27-32-30-7-3-1-5-28(30)29-6-2-4-8-31(29)32/h1-8,32H,9-27H2,(H,35,38)(H,36,37)
InChI Key:	VYXGUCLTEWCVRY-UHFFFAOYSA-N
Boiling Point:	781.1±60.0 °C at 760 mmHg
Purity:	≥95%
Density:	1.190±0.06 g/cm3
Solubility:	Soluble in DMSO (10 mm)
Appearance:	Colourless to pale yellow liquid
Storage:	Store at -20°C, keep in dry and avoid sunlight
LogP:	3.52350

Publication Number	Title	Priority Date
WO-2021151031-A1	Protein-antiviral compound conjugates	20200124
CA-3058663-A1	Trifunctional constructs with tunable pharmacokinetics useful in imaging and anti-tumor therapies	20170405
EP-3609541-A1	Trifunctional constructs with tunable pharmacokinetics useful in imaging and anti-tumor therapies	20170405
JP-2020516611-A	Trifunctional constructs with tunable pharmacokinetics useful in imaging and antitumor therapy	20170405
KR-20190129931-A	Trifunctional constructs with adjustable pharmacokinetics useful for imaging and anti-tumor therapy	20170405

Complexity:	783
Compound Is Canonicalized:	Yes
Covalently-Bonded Unit Count:	1
Defined Atom Stereocenter Count:	0
Defined Bond Stereocenter Count:	0
Exact Mass:	663.325476
Formal Charge:	0
Heavy Atom Count:	47
Hydrogen Bond Acceptor Count:	12
Hydrogen Bond Donor Count:	2
Isotope Atom Count:	0
Monoisotopic Mass:	663.325476
Rotatable Bond Count:	30
Topological Polar Surface Area:	150
Undefined Atom Stereocenter Count:	0
Undefined Bond Stereocenter Count:	0
XLogP3:	1.4