Flutrimazole - CAS 119006-77-8
Catalog: |
BB004364 |
Product Name: |
Flutrimazole |
CAS: |
119006-77-8 |
Synonyms: |
1-[(2-Fluorophenyl)(4-fluorophenyl)phenylmethyl]-1H-imidazole; UR 4056; 1-(o-Fluoro-α-(p-fluorophenyl)-α-phenylbenzyl)imidazole; 1H-Imidazole, 1-((2-fluorophenyl)(4-fluorophenyl)phenylmethyl)- |
Application: |
Antifungal Agents |
IUPAC Name: | 1-[(2-fluorophenyl)-(4-fluorophenyl)-phenylmethyl]imidazole |
Description: | Flutrimazole, an imidazole antifungal agent with anti-inflammatory activity, has potent and broad-spectrum in vitro activity against dermatophytes, filamentous fungi and yeasts. |
Molecular Weight: | 346.37 |
Molecular Formula: | C22H16F2N2 |
Canonical SMILES: | C1=CC=C(C=C1)C(C2=CC=C(C=C2)F)(C3=CC=CC=C3F)N4C=CN=C4 |
InChI: | InChI=1S/C22H16F2N2/c23-19-12-10-18(11-13-19)22(26-15-14-25-16-26,17-6-2-1-3-7-17)20-8-4-5-9-21(20)24/h1-16H |
InChI Key: | QHMWCHQXCUNUAK-UHFFFAOYSA-N |
Boiling Point: | 457.1±40.0°C (Predicted) |
Melting Point: | >150°C (dec.) |
Purity: | ≥95% |
Density: | 1.15±0.1 g/cm3 (Predicted) |
Solubility: | Soluble in DMSO (Slightly), Methanol (Slightly) |
Appearance: | White to Pale Yellow Solid |
Storage: | Store at -20°C |
LogP: | 5.00150 |
GHS Hazard Statement: | H302 (100%): Harmful if swallowed [Warning Acute toxicity, oral] |
Precautionary Statement: | P261, P264, P270, P271, P280, P301+P312, P302+P352, P304+P340, P305+P351+P338, P312, P321, P330, P332+P313, P337+P313, P362, P403+P233, P405, and P501 |
Signal Word: | Warning |
Publication Number | Title | Priority Date |
CN-112807306-A | Antifungal flutramazole shampoo preparation and preparation process thereof | 20210118 |
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WO-2021209815-A1 | Transdermal micro-dosing delivery of psychedelics derivatives | 20200416 |
WO-2021202926-A1 | Methods and combinations for dual targeting of tnf family members | 20200402 |
WO-2021202816-A1 | Broad-spectrum antiviral peptides | 20200331 |
PMID | Publication Date | Title | Journal |
19558428 | 20101101 | Study to compare the efficacy and safety of fluconazole cream with flutrimazole cream in the treatment of superficial mycosis: a multicentre, randomised, double-blind, phase III trial | Mycoses |
19750012 | 20090914 | Identification of antifungal compounds active against Candida albicans using an improved high-throughput Caenorhabditis elegans assay | PloS one |
19920897 | 20090206 | Pharmacological control of neutrophil-mediated inflammation: strategies targeting calcium handling by activated polymorphonuclear leukocytes | Drug design, development and therapy |
18394396 | 20080401 | [Facial dermatophytide reaction] | Anales de pediatria (Barcelona, Spain : 2003) |
17472615 | 20070501 | Flutrimazole shampoo 1% versus ketoconazole shampoo 2% in the treatment of pityriasis versicolor. A randomised double-blind comparative trial | Mycoses |
Complexity: | 445 |
Compound Is Canonicalized: | Yes |
Covalently-Bonded Unit Count: | 1 |
Defined Atom Stereocenter Count: | 0 |
Defined Bond Stereocenter Count: | 0 |
Exact Mass: | 346.12815484 |
Formal Charge: | 0 |
Heavy Atom Count: | 26 |
Hydrogen Bond Acceptor Count: | 3 |
Hydrogen Bond Donor Count: | 0 |
Isotope Atom Count: | 0 |
Monoisotopic Mass: | 346.12815484 |
Rotatable Bond Count: | 4 |
Topological Polar Surface Area: | 17.8 Å2 |
Undefined Atom Stereocenter Count: | 1 |
Undefined Bond Stereocenter Count: | 0 |
XLogP3: | 4.6 |
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