Distigmine Bromide - CAS 15876-67-2
Catalog: |
BB011462 |
Product Name: |
Distigmine Bromide |
CAS: |
15876-67-2 |
Synonyms: |
N-methyl-N-[6-[methyl-[(1-methyl-3-pyridin-1-iumyl)oxy-oxomethyl]amino]hexyl]carbamic acid (1-methyl-3-pyridin-1-iumyl) ester;dibromide; (1-methylpyridin-1-ium-3-yl) N-methyl-N-[6-[methyl-(1-methylpyridin-1-ium-3-yl)oxycarbonylamino]hexyl]carbamate;dibromide |
IUPAC Name: | (1-methylpyridin-1-ium-3-yl) N-methyl-N-[6-[methyl-(1-methylpyridin-1-ium-3-yl)oxycarbonylamino]hexyl]carbamate;dibromide |
Description: | Distigmine Bromide (CAS# 15876-67-2) is a cholinesterase inhibitor. |
Molecular Weight: | 576.32 |
Molecular Formula: | C22H32Br2N4O4 |
Canonical SMILES: | C[N+]1=CC=CC(=C1)OC(=O)N(C)CCCCCCN(C)C(=O)OC2=C[N+](=CC=C2)C.[Br-].[Br-] |
InChI: | InChI=1S/C22H32N4O4.2BrH/c1-23-13-9-11-19(17-23)29-21(27)25(3)15-7-5-6-8-16-26(4)22(28)30-20-12-10-14-24(2)18-20;;/h9-14,17-18H,5-8,15-16H2,1-4H3;2*1H/q+2;;/p-2 |
InChI Key: | GJHSNEVFXQVOHR-UHFFFAOYSA-L |
LogP: | -3.53460 |
GHS Hazard Statement: | H300 (100%): Fatal if swallowed [Danger Acute toxicity, oral] |
Precautionary Statement: | P264, P270, P273, P301+P310, P321, P330, P405, and P501 |
Signal Word: | Danger |
Publication Number | Title | Priority Date |
JP-2021152047-A | Aqueous liquid | 20201118 |
WO-2021195256-A1 | Pharmaceutical preparation | 20200324 |
US-10980756-B1 | Methods of treatment | 20200316 |
JP-2021138696-A | Aqueous suspension | 20200306 |
JP-2021133111-A | Inner plug and eye drop container that make up the nozzle | 20200228 |
PMID | Publication Date | Title | Journal |
22971686 | 20120901 | Cholinergic drugs for treatment of recurrent urinary retention in high surgical risk/elderly BPH patients. A pilot study | Minerva urologica e nefrologica = The Italian journal of urology and nephrology |
22221137 | 20120501 | Effect of distigmine combined with propiverine on bladder activity in rats with spinal cord injury | International journal of urology : official journal of the Japanese Urological Association |
22138106 | 20120201 | Effects of a peripheral cholinesterase inhibitor on cytokine production and autonomic nervous activity in a rat model of sepsis | Cytokine |
22352046 | 20111201 | [Acute respiratory failure associated with cholinergic crisis: report of five cases and review of the literature] | Nihon Kokyuki Gakkai zasshi = the journal of the Japanese Respiratory Society |
21077286 | 20101001 | [Establishing indicators for diagnosis of cholinergic crisis] | Rinsho byori. The Japanese journal of clinical pathology |
Complexity: | 487 |
Compound Is Canonicalized: | Yes |
Covalently-Bonded Unit Count: | 3 |
Defined Atom Stereocenter Count: | 0 |
Defined Bond Stereocenter Count: | 0 |
Exact Mass: | 576.07698 |
Formal Charge: | 0 |
Heavy Atom Count: | 32 |
Hydrogen Bond Acceptor Count: | 6 |
Hydrogen Bond Donor Count: | 0 |
Isotope Atom Count: | 0 |
Monoisotopic Mass: | 574.07903 |
Rotatable Bond Count: | 11 |
Topological Polar Surface Area: | 66.8 Å2 |
Undefined Atom Stereocenter Count: | 0 |
Undefined Bond Stereocenter Count: | 0 |
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