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| Description: | Dimethyl ((R)-4-Oxo-4-(3-(trifluoromethyl)-5,6-dihydro-[1,2,4]triazolo[4,3-a]pyrazin-7(8H)-yl)-1-(2,4,5-trifluorophenyl)butan-2-yl)aspartate is an intermediate in the synthesis of (R)-Sitagliptin rac-Fumarate Adduct (S491040) which is an impurity of Sitagliptin (S491000), a trizolopyrazine dipeptidyl peptidase IV inhibitor. Sitagliptin has recently been approved for the therapy of type II diabetes. |
| Molecular Weight: | 551.45 |
| Molecular Formula: | C22H23F6N5O5 |
| References: | Kim, D., et al. J. Med. Chem. 48, 141 (2005), Ahren, B., et al. Eur. J. Pharmacol. 521 164 (2005), Bergman, A., et al: Clin. Ther. 28, 55 (2006). |
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