Diiodohydroxyquinoline - CAS 83-73-8

Name: Diiodohydroxyquinoline
Brand: BOC Sciences
Rating: 5 (1 reviews)

Catalog:	BB037083
Product Name:	Diiodohydroxyquinoline
CAS:	83-73-8
Synonyms:	iodoquinol;83-73-8;Diiodohydroxyquinoline;5,7-diiodoquinolin-8-ol;5,7-Diiodo-8-hydroxyquinoline;5,7-Diiodo-8-quinolinol;Diiodoquin;Diodoquin;Yodoxin;DIIODOHYDROXYQUIN;Lanodoxin;Searlequin;Zoaquin;Ioquin;Quinadome;Sebaquin;8-Quinolinol, 5,7-diiodo-;Diodohydroxyquin;Dijodoxichinoline;Enterodiamoebin;Diamoebin;Dinoleine;Diodoquine;Diodoxylin;Direxiode;Disoquin;Embequin;Enterosept;Floraquin;Fluoraquin;Moebiquin;Dyodin;Di-quinol;Stanquinate;Rafamebin;5,7-Diiodo-oxine;Ioquin suspension;Dijodoxichinolinum;8-Hydroxy-5,7-diiodoquinoline;5,7-Diodo-8-quinolinol;Diodoxyquinoleine;Diiodoidrossichinolina;Panaquin;Diiodohidroxiquinoleina;Diiodohydroxyquinoleine;Diiodohydroxyquinolinum;SS 578;Enterodiamoebine;NSC 8704;NSC-8704;5,7-Diiod-8-chinolinol [IUPAC];Diiodohydroxyquinoline [INN];MLS000069404;CHEBI:5950;DTXSID6023155;63W7IE88K8;MMV002817;SS-578;NCGC00018098-04;SMR000059090;C9H5I2NO;Diiodohydroxyquinoline (INN);Iodoquinol [USAN];DTXCID003155;Caswell No. 354;Iodoquinol;5,7-Diiodo-8-hydroxyquinoline;5,7-Diiodo-8-quinolinol;CAS-83-73-8;Diiodoidrossichinolina [DCIT];HSDB 3224;SR-01000002969;Diiodohydroxyquinolinum [INN-Latin];Iodoquinol [USAN:USP];Diiodohydroxyquinoleine [INN-French];EINECS 201-497-9;5,7-Diiod-8-chinolinol;Diiodohidroxiquinoleina [INN-Spanish];EPA Pesticide Chemical Code 024003;BRN 0153639;Searlewuin;Meobiquin;UNII-63W7IE88K8;AI3-16443;5,7-Diiodooxine;component of Vytone;Iodoquinol (USP);Yodoxin (TN);MFCD00006789;Spectrum_000943;IODOQUINOL [MI];8-Quinolinol,7-diiodo-;Spectrum2_001041;Spectrum3_000470;Spectrum4_000020;Spectrum5_000872;IODOQUINOL [HSDB];4,7-Diiodo-8-quinolinol;bmse000836;EC 201-497-9;cid_3728;SCHEMBL3460;IODOQUINOL [USP-RS];BSPBio_002180;CBDivE_011080;KBioGR_000399;KBioSS_001423;ksc-8-193;CHEMBL86754;DivK1c_000119;SPECTRUM1500353;SPBio_000962;DI-IODOHYDROXY QUINOLINE;5,7-bis(iodanyl)quinolin-8-ol;BDBM66035;HMS500F21;KBio1_000119;KBio2_001423;KBio2_003991;KBio2_006559;KBio3_001400;UXZFQZANDVDGMM-UHFFFAOYSA-;IODOQUINOL [USP IMPURITY];NSC8704;NINDS_000119;WLN: T66 BNJ GI II JQ;HMS1920H05;HMS2091N15;HMS2230G24;HMS3369C20;IODOQUINOL [USP MONOGRAPH];KUC105860N;Pharmakon1600-01500353;HY-B1400;Tox21_110823;CCG-40132;NSC757077;s4565;STK070581;DIIODOHYDROXYQUINOLINE [MART.];AKOS000120804;Tox21_110823_1;5,7-Diiodo-8-hydroxyquinoline, 97%;CS-4910;DB09115;DIIODOHYDROXYQUINOLINE [WHO-DD];Iodoquinol (5,7-Diiodoquinolin-8-ol);NSC-757077;IDI1_000119;NCGC00018098-01;NCGC00018098-02;NCGC00018098-03;NCGC00018098-05;NCGC00018098-07;NCGC00018098-08;NCGC00021685-03;NCGC00021685-04;DS-17759;SBI-0051417.P003;DB-056739;AM20061527;D1736;NS00003663;EN300-18288;C07636;D00581;F12461;AB00052024_12;AN-329/13210059;Q5276473;SR-01000002969-2;SR-01000002969-5;BRD-K75855670-001-06-8;BRD-K75855670-001-14-2;Z57825347;F3034-0058;Iodoquinol, United States Pharmacopeia (USP) Reference Standard;InChI=1/C9H5I2NO/c10-6-4-7(11)9(13)8-5(6)2-1-3-12-8/h1-4,13H;
Application:	5,7-Diiodo-8-Quinolinol is active against both cyst and trophozoites that are localized in the lumen of the intestine. It is used in the treatment of amoebiasis. It is considered the drug of choice for treating asymptomatic or moderate forms of amebiasis.

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Computed Properties

IUPAC Name:	5,7-diiodoquinolin-8-ol
Description:	5,7-Diiodo-8-Quinolinol is a topical therapeutic agent with satisfactory antibacterial properties. It is poorly absorbed from the gastrointestinal tract and is used as a luminal amebicide. It acts by chelation of ferrous ions essential for metabolism. It is active against both cyst and trophozoites that are localized in the lumen of the intestine. It is used in the treatment of amoebiasis. It is considered the drug of choice for treating asymptomatic or moderate forms of amebiasis. It was discovered by Adco Co.
Molecular Weight:	530.5
Molecular Formula:	C26H26O12
Canonical SMILES:	COC(=O)[C@@]1(C[C@H]([C@H]([C@@H](C1)OC(=O)/C=C/C2=CC(=C(C=C2)O)O)OC(=O)/C=C/C3=CC(=C(C=C3)O)O)O)O
InChI:	InChI=1S/C9H5I2NO/c10-6-4-7(11)9(13)8-5(6)2-1-3-12-8/h1-4,13H
InChI Key:	UXZFQZANDVDGMM-UHFFFAOYSA-N
Boiling Point:	401.8±45.0 °C \| Condition: Press: 760 Torr
Melting Point:	210 °C
Purity:	98 %
Density:	2.491±0.06 g/cm³ \| Condition: Temp: 20 °C Press: 760 Torr
Solubility:	10 mM in DMSO
Appearance:	Yellow to tan powder or crystals
Storage:	Please store the product under the recommended conditions in the Certificate of Analysis.
MDL:	MFCD00006789
LogP:	3.14960
Quality Standard:	USP standard
Stability:	Stable in air

GHS Hazard Statement:	H302 (98.46%): Harmful if swallowed [Warning Acute toxicity, oral]
Precautionary Statement:	P261, P264, P270, P271, P280, P301+P312, P302+P352, P304+P312, P304+P340, P305+P351+P338, P310, P312, P321, P322, P330, P332+P313, P337+P313, P362, P363, P403+P233, P405, and P501
Signal Word:	Danger

Publication Number	Title	Priority Date
CN-113292492-A	Method for preparing clioquinol and diiodoquinol by one-pot method	20210610
WO-2021207801-A1	Immune cells with enhanced function	20200417
US-2021322447-A1	Transdermal micro-dosing delivery of psychedelics derivatives	20200416
WO-2021209815-A1	Transdermal micro-dosing delivery of psychedelics derivatives	20200416
KR-20200043944-A	Bioactive substance deleviry carrier	20200413

PMID	Publication Date	Title	Journal
32473310	20200901	Discovery of the FDA-approved drugs bexarotene, cetilistat, diiodohydroxyquinoline, and abiraterone as potential COVID-19 treatments with a robust two-tier screening system	Pharmacological research
23769903	20130905	FDA-approved drugs and other compounds tested as inhibitors of human glutathione transferase P1-1	Chemico-biological interactions
23571415	20130601	Structure-based identification of OATP1B1/3 inhibitors	Molecular pharmacology
22382561	20120101	Pleural empyema secondary to rupture of amoebic liver abscess	Internal medicine (Tokyo, Japan)
22577371	20120101	Double-blind, placebo-controlled, randomized study comparing 0.0003% calcitriol with 0.1% tacrolimus ointments for the treatment of endemic pityriasis alba	Dermatology research and practice

Complexity:	191
Compound Is Canonicalized:	Yes
Covalently-Bonded Unit Count:	1
Defined Atom Stereocenter Count:	0
Defined Bond Stereocenter Count:	0
Exact Mass:	396.84606
Formal Charge:	0
Heavy Atom Count:	13
Hydrogen Bond Acceptor Count:	2
Hydrogen Bond Donor Count:	1
Isotope Atom Count:	0
Monoisotopic Mass:	396.84606
Rotatable Bond Count:	0
Topological Polar Surface Area:	33.1 Å²
Undefined Atom Stereocenter Count:	0
Undefined Bond Stereocenter Count:	0
XLogP3:	3.1

Diiodohydroxyquinoline - CAS 83-73-8

Technical Data

Safety and Hazards

Patents

Literatures

Computed Properties

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