Difluoromethyl 2-pyridyl sulfone - CAS 1219454-89-3

Catalog:	BB005302
Product Name:	Difluoromethyl 2-pyridyl sulfone
CAS:	1219454-89-3
Synonyms:	2-(difluoromethylsulfonyl)pyridine

Technical Data

Safety and Hazards

Patents

Literatures

Computed Properties

IUPAC Name:	2-(difluoromethylsulfonyl)pyridine
Description:	Difluoromethyl 2-pyridyl sulfone (CAS# 1219454-89-3) is a new novel gem-difluoroolefination reagent for both aldehydes and ketones.
Molecular Weight:	193.17
Molecular Formula:	C6H5F2NO2S
Canonical SMILES:	C1=CC=NC(=C1)S(=O)(=O)C(F)F
InChI:	InChI=1S/C6H5F2NO2S/c7-6(8)12(10,11)5-3-1-2-4-9-5/h1-4,6H
InChI Key:	YRQNSTAWTLXCEZ-UHFFFAOYSA-N
Storage:	Keep in dark place, Inert atmosphere, Store in freezer, under -20 °C
LogP:	2.15870

Publication Number	Title	Priority Date
WO-2021026803-A1	Piperidinyl-methyl-purineamines as nsd2 inhibitors and anti-cancer agents	20190814
WO-2021028854-A1	Piperidinyl-methyl-purineamines as nsd2 inhibitors and anti-cancer agents	20190814
WO-2020121261-A1	3,3-difluoroallylamines or salts thereof and pharmaceutical compositions comprising the same	20181214
WO-2020121263-A1	Triazolopyridin-3-ones or their salts and pharmaceutical compositions comprising the same	20181214
US-2020223827-A1	3,3-difluoroallylamines or salts thereof and pharmaceutical compositions comprising the same	20181214

PMID	Publication Date	Title	Journal
21370337	20110307	From difluoromethyl 2-pyridyl sulfone to difluorinated sulfonates: a protocol for nucleophilic difluoro(sulfonato)methylation	Angewandte Chemie (International ed. in English)
20210302	20100402	Difluoromethyl 2-pyridyl sulfone: a new gem-difluoroolefination reagent for aldehydes and ketones	Organic letters

Related Products

Online Inquiry

Name:

* Phone:

* Service & Products of Interested:

Project Description:

* Quantity:

* Email:

* Verification Code:

Customer Support

If the product you need is not in our catalog, please contact us in time to submit your needs. You can help our website get better and better. Why not submit the request today?

Submit Requirement

Customer Centered

Global Delivery

Warehouses in multiple cities to ensure fast delivery

Quality Assurance

Strict process parameter control to ensure product quality

Large Stock

> 20,000 building blocks and intermediates from stock

Process Scale-up

Process scale-up from lab to industrial scale

Flexible Batch Size

Flexible batch size for diverse industrial demands

Related Functional Groups

Fluorinated Building Blocks

[1866059-82-6]
1,1,2,2-Tetrafluoro-3-methylsulfonylpropane
[2454490-85-6]
2-(7,8-Difluoro-1-naphthyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane
[865774-78-3]
2-(6,8-difluoro-1,2,3,4-tetrahydro-naphthalen-2-ylamino)-pentanoic acid methyl ester
[459836-92-1]
3,6-Difluoro-2-methylbenzoic acid
[150517-77-4]
3-Fluoro-5-(trifluoromethyl)benzylamine
[5310-68-9]
4-Chlorophenylsulphur pentafluoride

Other Pyrimidines

[1183749-69-0]
2-(pyrimidin-2-yloxy)phenol
[2696462-69-6]
4-(4-Aminopyrimidin-2-yl)-2-methyl-1-(2-trimethylsilylethoxymethyl)pyrazol-3-one
[927800-47-3]
4-Chloro-6-fluoro-2-trichloromethyl-quinoline
[207605-39-8]
trans-2,3,4,5,6-Pentafluoro-β-nitrostyrene
[1160246-50-3]
2-((4-(P-Tolyl)-6-(trifluoromethyl)pyrimidin-2-yl)oxy)ethanamine
[860790-29-0]
N-[4-Cyclopropyl-6-(trifluoromethyl)pyrimidin-2-yl]propane-1,3-diamine

Pyridines

[14993-80-7]
2-(6-Methylpyridin-2-yl)acetonitrile
[76167-49-2]
2-(Pyridin-3-yloxy)aniline
[942206-23-7]
2,5-Dichloro-3-iodopyridine
[856848-33-4]
2-Amino-4,5-dibromopyridine
[267242-99-9]
2-Chloro-4-methyl-6,7-dihydro-5H-cyclopenta[b]pyridine
[7356-60-7]
3-Amidinopyridine Hydrochloride

GHS Hazard Statement:	H301 (97.44%): Toxic if swallowed [Danger Acute toxicity, oral]
Precautionary Statement:	P264, P270, P280, P301+P310, P305+P351+P338, P321, P330, P337+P313, P405, and P501
Signal Word:	Danger

Complexity:	234
Compound Is Canonicalized:	Yes
Covalently-Bonded Unit Count:	1
Defined Atom Stereocenter Count:	0
Defined Bond Stereocenter Count:	0
Exact Mass:	193.00090590
Formal Charge:	0
Heavy Atom Count:	12
Hydrogen Bond Acceptor Count:	5
Hydrogen Bond Donor Count:	0
Isotope Atom Count:	0
Monoisotopic Mass:	193.00090590
Rotatable Bond Count:	2
Topological Polar Surface Area:	55.4 Å²
Undefined Atom Stereocenter Count:	0
Undefined Bond Stereocenter Count:	0
XLogP3:	1.4