Di(tert-butyl)(2',4',6'-triisopropyl-3,6-dimethoxybiphenyl-2-yl)phosphine - CAS 1160861-53-9
Catalog: |
BB003708 |
Product Name: |
Di(tert-butyl)(2',4',6'-triisopropyl-3,6-dimethoxybiphenyl-2-yl)phosphine |
CAS: |
1160861-53-9 |
Synonyms: |
ditert-butyl-[3,6-dimethoxy-2-[2,4,6-tri(propan-2-yl)phenyl]phenyl]phosphine; ditert-butyl-[3,6-dimethoxy-2-[2,4,6-tri(propan-2-yl)phenyl]phenyl]phosphane |
IUPAC Name: | ditert-butyl-[3,6-dimethoxy-2-[2,4,6-tri(propan-2-yl)phenyl]phenyl]phosphane |
Description: | Buchwald Phosphine Ligands for chemical Synthesis Common applications; Buchwald-Hartwig amination and C-O coupling; Suzuki, Negishi, Stille, Hiyama, Sonogashira cross-couplings; α-Arylation reactionNew Applications: Conversion of aryl and vinyl triflates to bromides and chlorides; Conversion of aryl triflates to aryl fluorides; O-Arylation of ethyl acetohydroximate; Conversion of aryl chlorides and sulfonates to nitroaromatics. |
Molecular Weight: | 484.69 |
Molecular Formula: | C31H49O2P |
Canonical SMILES: | CC(C)C1=CC(=C(C(=C1)C(C)C)C2=C(C=CC(=C2P(C(C)(C)C)C(C)(C)C)OC)OC)C(C)C |
InChI: | InChI=1S/C31H49O2P/c1-19(2)22-17-23(20(3)4)27(24(18-22)21(5)6)28-25(32-13)15-16-26(33-14)29(28)34(30(7,8)9)31(10,11)12/h15-21H,1-14H3 |
InChI Key: | REWLCYPYZCHYSS-UHFFFAOYSA-N |
Melting Point: | 166-170 °C |
Flash Point: | Not applicable |
Purity: | 97 % |
MDL: | MFCD13181930 |
LogP: | 9.44520 |
GHS Hazard Statement: | H315 (100%): Causes skin irritation [Warning Skin corrosion/irritation] |
Precautionary Statement: | P261, P264, P271, P280, P302+P352, P304+P340, P305+P351+P338, P312, P321, P332+P313, P337+P313, P362, P403+P233, P405, and P501 |
Signal Word: | Warning |
Publication Number | Title | Priority Date |
WO-2021204774-A1 | Pd-CATALYZED AMINATION OF FLUORINATED ARYL CHLORIDES | 20200410 |
WO-2021198020-A1 | 3-(anilino)-2-[3-(3-alkoxy-pyridin-4-yl]-1,5,6,7-tetrahydro-4h-pyrrolo[3,2-c]pyridin-4-one derivatives as egfr inhibitors for the treatment of cancer | 20200331 |
WO-2021178420-A1 | Compounds targeting rna-binding proteins or rna-modifying proteins | 20200303 |
WO-2021177290-A1 | Method for producing mono-cross-coupled aromatic compound having leaving group | 20200302 |
WO-2021174164-A1 | Compounds and methods for modulating splicing | 20200228 |
PMID | Publication Date | Title | Journal |
21999801 | 20111116 | Evidence for in situ catalyst modification during the Pd-catalyzed conversion of aryl triflates to aryl fluorides | Journal of the American Chemical Society |
Complexity: | 582 |
Compound Is Canonicalized: | Yes |
Covalently-Bonded Unit Count: | 1 |
Defined Atom Stereocenter Count: | 0 |
Defined Bond Stereocenter Count: | 0 |
Exact Mass: | 484.34701780 |
Formal Charge: | 0 |
Heavy Atom Count: | 34 |
Hydrogen Bond Acceptor Count: | 2 |
Hydrogen Bond Donor Count: | 0 |
Isotope Atom Count: | 0 |
Monoisotopic Mass: | 484.34701780 |
Rotatable Bond Count: | 9 |
Topological Polar Surface Area: | 18.5 Å2 |
Undefined Atom Stereocenter Count: | 0 |
Undefined Bond Stereocenter Count: | 0 |
XLogP3: | 8.4 |
Online Inquiry
Customer Support
Customer Centered
Related Functional Groups
Phosphorus Compounds
Customers Also Viewed
INDUSTRY LEADERS TRUST OUR PRODUCTS